|Western Blot (WB)||1/500 - 1/2000|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of human XBP1 expressed in E. Coli.|
|Contains||0.03% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA5-15626 targets XBP1 in WB applications and shows reactivity with Human samples.
The MA5-15626 immunogen is purified recombinant fragment of human XBP1 expressed in E. Coli.
MA5-15626 detects XBP1 which has a predicted molecular weight of approximately 28kDa.
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum , the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1, which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1, is constitutively expressed, and thought to function as a negative feedback regulator of XBP1, which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Tax-responsive element-binding protein 5; TREB-5; TREB5; X-box-binding protein 1; XBP-1; XBP1; XBP2
Gene Aliases: TREB-5; TREB5; XBP-1; XBP1; XBP2
UniProt ID: (Human) P17861
Entrez Gene ID: (Human) 7494
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