|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
|Western Blot (WB)||See 7 publications below|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunocytochemistry (ICC)||See 2 publications below|
|Immunoprecipitation (IP)||See 3 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Hamster , Human|
|Host / Isotype||Mouse|
|Immunogen||Recombinant human XPF protein|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage conditions||4° C|
MA5-12054 targets XPF in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-12054 immunogen is recombinant human XPF protein.
The structure-specific ERCC1/XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV-induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross-links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: complementation group F; complementing defective; DNA excision repair protein ERCC-4; DNA repair endonuclease XPF; DNA repair protein complementing XP-F cells; excision repair cross-complementation group 4; excision repair cross-complementing rodent repair deficiency, complementation group 4; excision-repair; excision-repair, complementing defective, in Chinese hamster; in Chinese hamster; xeroderma pigmentosum; Xeroderma pigmentosum group F-complementing protein; xeroderma pigmentosum, complementation group F
Gene Aliases: ERCC11; ERCC4; FANCQ; RAD1; XFEPS; XPF
UniProt ID: (Human) Q92889
Entrez Gene ID: (Human) 2072
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