|Immunohistochemistry (Paraffin) (IHC (P))||2-4ug/ml|
|Western Blot (WB)||0.01-0.03 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (KSQNKPEDEADE) corresponding to the internal amino acids of LDB3|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with canine, mouse, porcine and rat based on sequence homology.
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms have C-terminal LIM domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cardiomyopathy, dilated 1C (autosomal dominant); CYPHER; FLJ35865; HGNC:15710; KIAA01613; KIAA0613; LDB3; ldb3z1; ldb3z4; LIM domain binding 3; LIM domain-binding protein 3; ORACLE; PDLIM6; PDZ and LIM domain 6; Protein cypher; Z-band alternatively spliced PDZ motif protein; Z-band alternatively spliced PDZ-motif; Z-band alternatively spliced PDZ-motif protein; ZASP
Gene Aliases: CMD1C; CMH24; CMPD3; CYPHER; KIAA0613; LDB3; LDB3Z1; LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP
UniProt ID: (Human) B4E3K3
Entrez Gene ID: (Human) 11155
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