|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 181-210 amino acids from the central region of human ZBTB7B|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: c-Krox; hcKrox; Krueppel-related zinc finger protein cKrox; T helper-inducing POZ/Krueppel factor; T-helper-inducing POZ/Krueppel-like factor; Vzinc finger and BTB domain containing 7B; Zfp-67; zinc finger and BTB domain containing 15; Zinc finger and BTB domain-containing protein 15; Zinc finger and BTB domain-containing protein 7B; Zinc finger protein 67; Zinc finger protein 67 homolog; Zinc finger protein 857B; Zinc finger protein Th-POK
Gene Aliases: c-KROX; CKROX; hcKROX; THPOK; ZBTB15; ZBTB7B; ZFP-67; ZFP67; ZNF857B
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