|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.1-1 µg/ml|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Dog, Human, Non-human primate|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 1250-1300 of human Zinc finger 198.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody is 94% homologous to mouse, rat, bovine and chicken samples and 76% homologous to xenopus.
Suggested positive control: mouse skeletal muscle lysate.
ZNF198 is a ubiquitously expressed nuclear protein whose physiological role is largely unknown. It consists of 5 N-terminal zinc finger motifs responsible for protein-protein interactions, a central proline-rich domain and C-terminal nuclear localization signal (NLS) and an acidic domain. Reciprocal chromosomal translocation involving ZNF198 and FGFR1 results in the formation of ZNF198/FGFR1 fusion kinase protein. This fusion protein is a ligand-dependent, constitutively active cytoplasmic tyrosine kinase and regulates several STAT transcription factors including STAT 1, 3 and 5. This fusion protein is an oncogenic protein and is associated with an atypical myeloproliferative disease, peripheral blood eosinophilia and T-cell leukemia/lymphoma.
Protein Aliases: Fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder; Rearranged in atypical myeloproliferative disorder protein; Zinc finger MYM-type protein 2; Zinc finger protein 198; zinc finger, MYM-type 2; ZNF198
Gene Aliases: FIM; MYM; RAMP; SCLL; ZMYM2; ZNF198
UniProt ID: (Human) Q9UBW7