|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide derived from the internal region of human ZIC1/2/3/4/5|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: becoming restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. The Zic1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic1 gene contains a region-specific enhancer determined to be essential in in-vivo and in-vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family. Zic2 and Zic3 are highly similar genes. Zic2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation.; heterotaxy 1; odd-paired homolog; odd-paired related; Zic family member 1 (odd-paired homolog, Drosophila); Zic family member 2 (odd-paired homolog, Drosophila); Zic family member 3 (odd-paired homolog, Drosophila); Zic family member 4 (odd-paired homolog, Drosophila); Zic family member 5 (odd-paired homolog, Drosophila); Zic1 encodes a zinc finger protein expressed in the developing or matured central nervous system in a highly restricted manner. Zic is expressed in granule cells that make synaptic contact with Purkinje cells. Zic1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation; zinc family member 4 protein HZIC4; zinc family member 5 protein; Zinc finger protein 201; Zinc finger protein 203; Zinc finger protein of the cerebellum 1; Zinc finger protein of the cerebellum 2; Zinc finger protein of the cerebellum 3; Zinc finger protein of the cerebellum 4; Zinc finger protein of the cerebellum 5; Zinc finger protein ZIC 1; Zinc finger protein ZIC 2; Zinc finger protein ZIC 3; Zinc finger protein ZIC 4; Zinc finger protein ZIC 5
Gene Aliases: 1700049L20Rik; A930005G04Rik; Bn; CRS6; HPE5; HTX; HTX1; Ka; NOR-90; Opr; Tcfubf; UBF; UBF-1; UBF1; VACTERLX; ZIC; ZIC1; ZIC2; ZIC3; ZIC4; ZIC5; ZNF201; ZNF203
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