|Immunohistochemistry (Paraffin) (IHC (P))||1 µg/ml|
|Tested Species reactivity||Human, Rat|
|Host / Isotype||Sheep / IgG|
|Immunogen||Synthetic peptide corresponding to residues P(108) Q E G I L E D M P V D P C(120) of human alpha synuclein protein.|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-18258 detects alpha Synuclein from human and rat samples.
PA1-18258 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-18258 immunogen is a synthetic peptide corresponding to residues P(108) Q E G I L E D M P V D P C(120) of human alpha synuclein protein, conjugated to diphtheria toxoid.
Reconstitute with 50 ul of distilled water.
Synuclein family of proteins is abundantly expressed in neuronal cytosol and presynaptic terminals. In vertebrates they are encoded by three different genes. Synucleins have been specifically implemented in three major diseases: Alzheimer's (AD), Parkinson's PD) and breast cancer. In AD, a peptide derived from alpha synuclein forms an intrinsic component of plaque amyloid. In PD, an alpha synuclein accumulates in Lewy bodies. An allele of alpha synuclein has been linked to many familial cases of PD. In breast cancer increased expression of gamma synuclein correlates with the disease progression. Synucleins appear to be involved in the membrane plasticity in developing song control system of songbirds.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
Gene Aliases: NACP; PARK1; PARK4; PD1; SNCA
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.