|Immunohistochemistry (Paraffin) (IHC (P))||1:125|
|Immunohistochemistry (IHC)||See 1 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 2 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide derived from near the N-terminus of human beta-catenin|
|Storage buffer||tissue culture supernatant|
|Contains||15mM sodium azide|
|Storage conditions||4° C|
MA5-14461 targets beta-Catenin in IHC (P) applications and shows reactivity with Human samples.
The MA5-14461 immunogen is a synthetic peptide derived from near the N-terminus of human beta-catenin.
The catenins (alpha, beta and gamma) are ubiquitously expressed, cytoplasmic proteins associated with E-cadherin at cellular junctions. beta-catenin also binds to N-cadherin and co-immunoprecipitates with APC. Cadherin/catenin complexes are linked to the cytoskeleton via a direct association between alpha-actinin and alpha-catenin. Increased tyrosine phosphorylation can disrupt catenin-cadherin complexes, influencing cellular adhesion. Mutations in the catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin beta-1
Gene Aliases: armadillo; CTNNB; CTNNB1; MRD19; OK/SW-cl.35; PRO2286
UniProt ID: (Human) P35222
Entrez Gene ID: (Human) 1499
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