|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 314 and 538 of Human cIAP2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-29643 targets cIAP2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29643 immunogen is recombinant fragment corresponding to a region within amino acids 314 and 538 of Human cIAP2.
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: API2; Apoptosis inhibitor 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 3; C-IAP2; Cellular inhibitor of apoptosis 2; CIAP2; HAIP1; hIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; m; MALT2; mammalian IAP homolog C; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; RNF49; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1
Gene Aliases: AIP1; API2; BIRC3; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
UniProt ID: (Human) Q13489
Entrez Gene ID: (Human) 330
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