|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Tested Species reactivity||Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 223 and 449 of hnRNP H2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that binds to RNAs. It is very similar to the family member HNRPH1. This gene is thought to be involved in Fabray disease and X-linked agammaglobulinemia phenotype. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq].
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Protein Aliases: FTP3; Heterogeneous nuclear ribonucleoprotein H'; Heterogeneous nuclear ribonucleoprotein H2; heterogeneous nuclear ribonucleoprotein H2 H'; hnRNP H'; hnRNP H2; hnRNPH'; HNRNPH2; HNRPH'; HNRPH2
Gene Aliases: DXHXS1271E; Ftp-3; Ftp3; H'; HNRNP; Hnrnph2; Hnrph2
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