|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
|Western Blot (WB)||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide - KLH conjugated. Sequence identity/similarity to Rat: 19/38%.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
PA1-24562 detects Metabotropic Glutamate Receptor 4 in Human samples.
PA1-24562 has been successfully used in Immunohistochemistry (paraffin) and Western Blot procedures.
PA1-24562 immunogen corresponds to Synthetic peptide - KLH conjugated. Sequence identity/similarity to Rat: 19/38%.
The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties.
Protein Aliases: glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 4; mGluR4
Gene Aliases: GPRC1D; GRM4; mGlu4; MGLUR4
UniProt ID: (Human) Q14833
Entrez Gene ID: (Human) 2914