|Immunohistochemistry (Paraffin) (IHC (P))||Ready-to-use|
|Tested Species reactivity||Avian, Human, Mouse, Non-human primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (Human) (C-terminal).|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
PA1-21034 detects Metabotropic Glutamate Receptor 2 and 3 in Human, Mouse, Rat, Avian, and Non-human primate samples.
PA1-21034 has been successfully used in Immunohistochemistry (Paraffin) procedures.
PA1-21034 immunogen corresponds to synthetic peptide (Human) (C-terminal).
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Protein Aliases: G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member C; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 3; GPRC1B; GPRC1C; GRM2; GRM3; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 3; mGlu2; MGLUR2; mGluR3
Gene Aliases: 0710001G23Rik; 4930441L02Rik; GLUR2; GLUR3; GPRC1B; GPRC1C; GRM2; GRM3; mGlu2; mGlu3; MGLUR2; MGLUR3; mGluR7