|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: CEPRRETPKQSDVFFRHSKPPNRS (Human).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2, with 1mg/ml BSA|
|Contains||0.1% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-21740 detects p51A in Human and Mouse samples.
PA1-21740 has been successfully used in Immunocytochemistry and Western Blot procedures.
PA1-21740 immunogen corresponds to Synthetic peptide: CEPRRETPKQSDVFFRHSKPPNRS (Human)..
The p53 tumor suppressor gene, which is induced by DNA damage and /or stress stimuli, causes cells to undergo G1-arrest or apoptotic death. p51 protein is similar but distinct from p53. Unlike ubiquitous expression of p53, expression of p51 is restricted to skeletal muscle, placenta, mammary gland, prostrate, trachea, thymus, salivary gland, uterus, heart and lung. p51 has two major splice variants p51A that contains 448 amino acids and p51B that contains 641 amino acids. In p53-deficient cells, p51A indices growth suppression and apoptosis. Mutations in p51 have been found in some human epidermal tumors
Protein Aliases: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; Keratinocyte transcription factor KET; p40; p51; p63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like
Gene Aliases: AI462811; AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; P51/P63; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L; Trp53rp1; Trp63
Molecular Function: transcription factor