|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Rat, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 161 and 562 of Human tPA|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-27908 targets tPA in IHC (P) and WB applications and shows reactivity with Human, mouse and rat samples.
The PA5-27908 immunogen is recombinant fragment corresponding to a region within amino acids 161 and 562 of Human tPA.
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alteplase; plasminogen activator; plasminogen activator, tissue type; reteplase; T-PA; t-plasminogen activator; tissue plasminogen activator; tissue plasminogen activator (t-PA); tissue type; tissue-type plasminogen activator; TPA
Gene Aliases: AU020998; AW212668; D8Ertd2e; PATISS; T-PA; TPA
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