MSACL-CQ5-Header-950x220
Tradeshow
Sep 12, 2016 - Sep 15, 2016
Salzburg Congress Center

What you do in clinical research changes the world one life at a time

Are you looking to minimize cost and maximize efficiency?
Demanding simple answers from complex samples?
Looking for new disease protein biomarkers?
Automate your mass spectrometry workflow?

Join us at MSACL 2016!

Visit us on Booth #12-13. Discover our portfolio of chromatography, mass spectrometry, and automated sample preparation solutions. Hear about the latest developments in workflow automation, online-sample preparation, and simplified data analysis. Register for our free workshop to discover how our technology enables you to reach throughput efficiency unrealized with other solutions.

Workshops

Microsampling techniques and LC-MS/MS: therapeutic drug monitoring research to help personalize medicine for our children

Neonates, infants, and children undergo major and rapid age-related physiologic and biochemical changes, especially during the first year of life, resulting in different clinical pharmacokinetic (PK) and pharmacodynamic (PD) parameters from adults. Considerably, approximately 10% of all drugs prescribed are for children so the majority of prescriptions are off-label. Premature infants in neonatal intensive care units can receive up to twenty drugs during their hospital stay and blood levels in many of these patients need to be monitored by the laboratory. The availability of reliable analytical methods and microsampling techniques is thus crucial for therapeutic drug monitoring (TDM) and for the conduct of clinical PK studies inpediatric research, especially for low birth weight neonates. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is the analytical technique of choice which guarantees high specificity, accuracy and reproducibility. Sensitivity is of fundamental importance, not only in order to limit blood sample volume but also in order to simplify sample preparation procedures and improve throughput. In this context, alternative sampling strategies such as dried blood spot, volumetric microsampling devices and dried plasma spot have an emerging role. This workshop will explore analytical challenges and opportunities and possible application to routine clinical analysis. 

Giuliana Cangemi, PhD, MSC - Istituto Giannina Gaslini Children's Hospital in Genoa, Italy

Wednesday 14 September  |  08:00 - 08:45  | Papageno Room

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Speeding up the cancer biomarker discovery: Advanced Clinical Proteomics workflow with High Resolution MS

Adoption of cancer biomarkers in clinical labs has been plagued by the speed with which these biomarkers are discovered and validated for clinical use. Clinical proteomics approaches where the use of predefined set of surrogate peptides for proteins has been helpful in systematically identifying these markers. Targeted analyses using parallel reaction monitoring (PRM), performed on high resolution and accurate-mass (HRAM) quadrupole-orbitrap mass spectrometers, present the selectivity and sensitivity to confidently quantify peptides in complex samples. The internal standards (IS) used for isotope dilution quantification were recently leveraged to actually drive the acquisition (“internal standard triggered-parallel reaction monitoring”, IS-PRM), thus improving the acquisition efficiency. The application of this advanced PRM method was investigated for clinical proteomics, involving high-throughput screening and accurate quantification. Analyses of lung cancer markers in clinical plasma samples illustrating an advanced workflow automation and improved portability of the developed assays will be discussed in detail.  Learn what it takes to uncover biomarkers faster for future use in predictive diagnostic.

Sebastien Gallien, former researcher at CRP-Santé LIH Luxembourg Institute of Health, Thermo Fisher Scientific

Wednesday 14 September  |  14:00 - 14:45  | Papageno Room

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Featured products

Unless otherwise noted, all products are for research only, not for use in diagnostic procedures.

Featured products

Unless otherwise noted, all products are for research use only, not for use in diagnostic procedures.

Featured products

Unless otherwise noted, all products are for research use only, not for use in diagnostic procedures.

MSACL-event-image

Featured posters 

          Day/time     Poster Title Session Number

Wed 12:30

High-Throughput LC-MS/MS Measurement of Pregnenolone in Human Blood Serum for Research Purposes

Bioinformatics

# A2

Wed 12:30

Development of a High-throughput Hemoglobinopathies Workflow using High Resolution Accurate Mass Analysis

Proteomics

# P5

Wed 12:30

High-Throughput LC-MS/MS Measurement of 17-Hydroxyprogesterone in Human Blood Serum for Research Purposes

Small Molecules

# T3

Thurs 12:30

A Method for the Quantification of PEth 16:0/18:1 in Human Blood Based on UHPLC and Orbitrap High Resolution Accurate Mass spectrometry (HRAM)

Small Molecules

# B7

Thurs 12:30

Quantification of 25-OH Vitamin D2 and D3 with Chromatographic Resolution of the C3-epimer in Human Plasma or Serum by Liquid Chromatography Mass Spectrometry

Small Molecules

# F8

Thurs 12:30

Method Development Considerations for Paper-Spray Mass Spectrometry - Direct Ionization Technique for Physiological Fluid Analysis

Small Molecules

# G6

Thurs 12:30

Increasing Sample Throughput for Detecting Drugs of Abuse and Metabolites in Urine by UHPLCMS/ MS for Forensic Toxicology

Small Molecules

# K2

Thurs 12:30

Quantification of Total Homocysteine in Human Plasma or Serum by Liquid Chromatography Tandem Mass Spectrometry

Small Molecules

# M4

Thurs 12:30

Assessing Ion Suppression in On-Line Solid Phase Extraction LC-MS/MS

Troubleshooting Forum

# T4

Thurs 18:30

Flexibility of Multichannel HPLC with a Single Mass Spectrometer to Simplify Workflow Complexity and to Improve Throughput of LC-MS

Small Molecules

# J1

Thurs 18:30

Evaluation of the Analytical Parameters for Sensitive and Robust Quantitative Analysis of Catecholamines in Human Plasma with LC-MS for Research

Small Molecules

# K3

Routine clinical testing

Achieve greater productivity and confidence when providing laboratory-developed-test results to the healthcare professionals you serve with Thermo Scientific™ high-performance Class I medical devices for in vitro diagnostic use.

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Clinical and translational research

We are committed to providing reliable and easy-to-use solutions, service, and support to help meet the demanding needs of clinical and translational research, from scalable translational research solutions to proven clinical laboratory services and diagnostics.

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Venue Location

Salzburg Congress Center
Auerspergstraße 6
5020 Salzburg
AUSTRIA