One of the major challenges for adopting LC-MS technology is the limited throughput and automation compared to typical clinical chemistry instruments. This is an important issue because in the areas of toxicology, endocrinology, and therapeutic drug monitoring there are some important applications for which there are no commercial solutions. Laboratory developed tests using LC-MS and other technologies are needed to bridge this gap. In this webinar we discuss the opportunities and challenges for LC-MS in the clinical research laboratory, and describe ways that TurboFlow technology and multi-channel LC-MS systems increase efficiency and throughput. Examples will include methods to measure plasma renin activity and aldosterone concentration, rapid quantification of morphine and metabolites, and high-throughput quantification of antidepressant drugs.
For Research Use Only. Not for use in diagnostic procedures.
Dr. William Clarke, Associate Professor, Department of Pathology, and Director of both Point-of-Care Testing and Clinical Toxicology, Johns Hopkins
Dr. William Clarke received his Ph.D. in Analytical Chemistry from the University of Nebraska in Lincoln in 2000, followed by a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine, ending in 2002. In addition, he received an MBA focused on medical services management from the Carey School of Business at Johns Hopkins in 2007. Following his post-doctoral fellowship, he remained at Johns Hopkins, where he is an Associate Professor in the Department of Pathology, as well as the director of both Point-of-Care Testing and Clinical Toxicology for the hospital. Dr. Clarke is board certified in Clinical Chemistry by the American Board of Clinical Chemistry, and is a Fellow of the National Academy of Clinical Biochemistry. His research interests include clinical mass spectrometry, method development and evaluation for therapeutic drug monitoring, clinical toxicology, point-of-care testing, and development/validation of biomarkers for use in drug management. Dr. Clarke has published as author or co-author over 80 peer-reviewed manuscripts or book chapters.
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