The immune system attempts to constrain tumor growth, but sometimes tumor cells might escape or attenuate this immune pressure.
Cancer Biology Pathways
Browse cancer biology pathways
Cancer is a type of disease resulting from abnormal cell growth that has the possibility of metastasizing, or spreading to other parts of the body. Environmental toxins and genetic mutations can play a role in the development of tumors. Some of the most important pathways involved in cancer biology are the ErbB family pathway, the p53-mediated apoptosis pathway, and the GSK3 signaling pathway.
The ErbB family of transmembrane receptor tyrosine kinases (RTKs) plays an important role during the growth and development of organs.
GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.
Tumor protein p53 is a nuclear transcription factor that regulates the expression of a wide variety of genes involved in apoptosis, growth arrest, or senescence in response to genotoxic or cellular stress.
Members of the transforming growth factor (TGF)-beta family play an important role in the development, homeostasis, and repair of most tissues.
The liver is a major site for the formation and metastasis of tumors.
For Research Use Only. Not for use in diagnostic procedures.