Intercellular junctions are specialized regions on cell borders that allow connections between neighboring cells. Intercellular junctions can be organized into three functional groups:
- Occluding junctions–seal epithelial cells together to prevent leakage of molecules from one epithelial sheet to the other
- Anchoring junctions–mechanically link cells and their cytoskeletons to adjacent cells or to the extracellular matrix
- Communicating junctions–mediate the passage of chemical and electrical signals between interacting cells
Cell adhesion through intercellular junctions is essential to the body. A change in or loss of cell adhesion affects cell structure, cellular functioning and communication, and the extracellular matrix, which can result in severe health problems and diseases. Intercellular junction marker antibodies detect proteins specific to intercellular junctions and can aid in the study of the structure and functions of intercellular junctions. Intercellular junction marker antibodies can also help elucidate the role(s) that a protein may play in a number of tasks that are centered in or influenced by intercellular junctions. Quality Invitrogen intercellular junction marker antibodies are available for a variety of research needs.