Melanosomes are organelles that synthesize, store, and transport melanin. They are found in skin melanocytes, choroidal melanocytes, retinal pigment epithelial cells, and in melanophores of lower vertebrates. Melanosomes can produce melanin when human skin is exposed to ultraviolet radiation, after which they are transferred from melanocytes to nearby keratinocytes.

While melanosomes are vital for protecting the skin from UV radiation, the means by which melanosomes move is not fully understood. Melanosomal marker antibodies detect proteins specific to melanosomes and can aid in the study of the stucture and function of melanosomes. Melanosomal marker antibodies can also help elucidate the role or roles a protein may play in a number of tasks that are centered in or influenced by the melanosome. Quality Invitrogen melanosomal marker antibodies are available for a variety of research needs.

Melanosomal marker antibody targets

  • DCT
  • MART-1
  • PMEL
  • TYRP1

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Immunohistochemical staining of formalin-fixed, paraffin-embedded human melanoma. Specific detection was accomplished using a melanosome antibody (Cat. No. MA5-13232), a peroxidase-conjugate, and AEC chromogen. Note cytoplasmic staining of tumor cells.

Annotated product references

Cat. No. MA5-13232 was used in immunocytochemistry and western blot to study the role of the N-terminal region of PMEL in regulating the assembly of melanosomal fibrils. Molecular biology of the cell (Apr 2013; 24: 964) "Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils." Leonhardt RM,Vigneron N,Hee JS,Graham M,Cresswell P

Cat. No. MA5-13232 was used in immunocytochemistry and western blot to study the function of PMEL in pigment cells. PLoS genetics (Sep 2011; 7: ) "Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation." Hellström AR,Watt B,Fard SS,Tenza D,Mannström P,Narfström K,Ekesten B,Ito S,Wakamatsu K,Larsson J,Ulfendahl M,Kullander K,Raposo G,Kerje S,Hallböök F,Marks MS,Andersson L

Cat. No. MA5-15237 was used in western blot to study the proteolytic release of glycoprotein nonmetastatic melanoma protein b from melanosomes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (May 2010; 24: 1616) "Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein." Hoashi T,Sato S,Yamaguchi Y,Passeron T,Tamaki K,Hearing VJ