POROS resins for cation exchange

Cation exchange chromatography is a form of ion exchange chromatography in which a positively charged biomolecule binds to a negatively charged resin.

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POROS CEX resins are designed for high dynamic binding capacity over a range of pH and conductivity conditions, thereby increasing process development flexibility and manufacturing throughput. The particle size provides superior resolution for unprecedented impurity clearance independent of scale and flow rate. These 50 μm polymeric ion exchange chromatography resins can be used for the chromatographic separation of biomolecules, including recombinant proteins, monoclonal antibodies, DNA, viruses, and peptides. The resin backbone consists of crosslinked, rigid poly(styrene divinylbenzene). A polyhydroxyl surface coating provides low nonspecific binding, and surface functionalization with sulfopropyl yields a strong cation exchanger ionizable with pH 1–14.

POROS 50 μm HS and XS resins are strong cation exchange resins based on a sulfopropyl functionalization, designed for the purification of more basic proteins and biomolecules. They are especially well suited for the separation of process impurities and aggregates and are excellent choices for both capture and polishing applications. Both resins are designed for superior resolution; POROS XS delivers higher dynamic binding capacity at increased salt concentrations.

POROS XS delivers high capacity over a broad range of process conditions

Figure 1A. POROS XS resin has high capacity over a broad range of process conditions.

Figure 1B. POROS XS resin maintains high resolution as linear flow rate increases.

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