Optimized, automated assays for HCS
Understanding the mechanisms of cell death can provide key insights for toxicological profiling and drug discovery research. Apoptosis is a form of programmed cell death. A distinctive feature of the early stages of apoptosis is the activation of caspase enzymes, which participate in the cleavage of protein substrates and in the subsequent disassembly of the cell. We offer a caspase assay for HCS that allows the simple detection of active caspases in living cells in real time or in fixed cells.