| Application note |
Delivery solutions for immune cells |
CRISPR-Cas9 |
| Application note |
Improve genome editing outcomes in biologically relevant cell models |
CRISPR-Cas9, TALEN |
| Application note |
Using Sanger sequencing to facilitate CRISPR and TALEN-mediated genome editing workflows |
CRISPR-Cas9, TALEN |
| FAQs |
CRISPR-based genome editing—Getting Started FAQs |
CRISPR-Cas9 |
| FAQs |
CRISPR-based genome editing—Troubleshooting FAQs |
CRISPR-Cas9 |
| FAQs |
TALEN-based genome editing—Getting Started FAQs |
TALEN |
| FAQs |
TALEN-based genome editing—Troubleshooting FAQs |
TALEN |
| Infographic |
Genome Editing With Engineered Nucleases |
CRISPR-Cas9 |
| Infographic |
The Evolution of Genome Editing |
CRISPR-Cas9 |
| Protocol |
General CRISPR RNP Transfection Guidelines |
CRISPR-Cas9 |
| Protocol |
Verification of CRISPR Gene Editing Efficiency |
CRISPR-Cas9 |
| Protocol |
Guidelines For Clone Isolation and Validation |
CRISPR-Cas9 |
| Protocol |
Cell-Line Specific CRISPR RNP Transfection Conditions Using Lipofectamine CRISPRMAX Reagent |
CRISPR-Cas9 |
| Protocol |
Cell-Line Specific CRISPR RNP Electroporation Conditions Using Neon System |
CRISPR-Cas9 |
| Protocol |
Embryo Microinjection With CRISPR-Cas9 in Mice and Zebrafish |
CRISPR-Cas9 |
| Protocol |
CRISPR-Cas9 Genome Editing In Human Induced Pluripotent Stem Cell |
CRISPR-Cas9 |
| Publication (2016) |
Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA |
CRISPR-Cas9 |
| Publication (2016) |
Improved delivery of Cas9 protein/gRNA complexes using lipofectamine CRISPRMAX |
CRISPR-Cas9 |
| Publication (2015) |
Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection. |
CRISPR-Cas9 |
| Publication (2015) |
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. |
CRISPR-Cas9 |
| Publication (2015) |
Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease |
CRISPR-Cas9 |
| Publication (2015) |
Efficient Intracellular Delivery of Native Proteins |
CRISPR-Cas9 |
| Publication (2015) |
CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning. |
CRISPR-Cas9 |
| Publication (2015) |
Engineered CRISPR-Cas9 nucleases with altered PAM specificities |
CRISPR-Cas9 |
| Publication (2015) |
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers |
CRISPR-Cas9 |
| Publication (2015) |
Digienome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells |
CRISPR-Cas9 |
| Publication (2015) |
In vivo genome editing using Staphylococcus aureus Cas9 |
CRISPR-Cas9 |
| Publication (2015) |
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors |
CRISPR-Cas9 |
| Publication (2015) |
Multiplex conditional mutagenesis using transgenic expression of Cas9 and sgRNAs |
CRISPR-Cas9 |
| Publication (2015) |
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells |
CRISPR-Cas9 |
| Publication (2015) |
A Cas9–guide RNA complex preorganized for target DNA recognition |
CRISPR-Cas9 |
| Publication (2014) |
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases |
CRISPR-Cas9 |
| Publication (2014) |
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects |
CRISPR-Cas9 |
| Publication (2014) |
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 |
CRISPR-Cas9 |
| Publication (2014) |
Programmable RNA recognition and cleavage by CRISPR/Cas9 |
CRISPR-Cas9 |
| Publication (2014) |
Landscape of target: guide homology effects on Cas9-mediated cleavage |
CRISPR-Cas9 |
| Publication (2014) |
Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA |
CRISPR-Cas9 |
| Publication (2014) |
Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter |
CRISPR-Cas9 |
| Publication (2014) |
Crystal structure of Cas9 in complex with guide RNA and target DNA |
CRISPR-Cas9 |
| Publication (2014) |
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo |
CRISPR-Cas9 |
| Publication (2014) |
Guide RNA functional modules direct Cas9 activity and orthogonality |
CRISPR-Cas9 |
| Publication (2014) |
Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage |
CRISPR-Cas9 |
| Publication (2014) |
Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool |
CRISPR-Cas9 |
| Publication (2014) |
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases |
CRISPR-Cas9 |
| Publication (2014) |
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation |
CRISPR-Cas9 |
| Publication (2014) |
Improving CRISPR-Cas nuclease specificty using truncated guide RNAs |
CRISPR-Cas9 |
| Publication (2014) |
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease |
CRISPR-Cas9 |
| Publication (2014) |
High-throuput screening of a CRISPR/Cas9 library for functional genomics in human cells |
CRISPR-Cas9 |
| Publication (2014) |
CRISPR-mediated direct mutation of cancer genes in the mouse liver |
CRISPR-Cas9 |
| Publication (2014) |
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex |
CRISPR-Cas9 |
| Publication (2014) |
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation |
CRISPR-Cas9 |
| Publication (2014) |
High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zince finger nucleases or CRISPR/Cas9 nickase pairs |
CRISPR-Cas9 |
| Publication (2014) |
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences |
CRISPR-Cas9 |
| Publication (2014) |
Genome-Scale CRISPR-Cas9 knockout screening in human cells |
CRISPR-Cas9 |
| Publication (2014) |
Genetic screens in human cells using the CRISPR-Cas9 system |
CRISPR-Cas9 |
| Publication (2014) |
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells |
CRISPR-Cas9 |
| Publication (2014) |
Dimeric CRISPR RNA-guided FokI nucleases for efficient genome editing |
CRISPR-Cas9 |
| Publication (2014) |
CasOT: a genome-wide Cas9/gRNA off-target searching tool |
CRISPR-Cas9 |
| Publication (2014) |
Classification and evolution of type II CRISPR-Cas systems |
CRISPR-Cas9 |
| Publication (2014) |
Development and applications of CRISPR-Cas9 for genome engineering |
CRISPR-Cas9 |
| Publication (2014) |
Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease |
CRISPR-Cas9 |
| Publication (2014) |
Synthetic TAL effectors for targeted enhancement of transgene expression in plants |
TALEN |
| Publication (2013) |
Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes |
CRISPR-Cas9 |
| Publication (2013) |
Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions |
CRISPR-Cas9 |
| Publication (2013) |
Targeted Heritable Mutation and Gene Conversion by Cas9-CRISPR in Caenorhabditis elegans |
CRISPR-Cas9 |
| Publication (2013) |
Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas |
CRISPR-Cas9 |
| Publication (2013) |
The CRISPR/Cas System mediates efficient genome engineering in Bombyx mori |
CRISPR-Cas9 |
| Publication (2013) |
Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila |
CRISPR-Cas9 |
| Publication (2013) |
Efficient genome editing in zebrafish using a CRISPR-Cas system |
CRISPR-Cas9 |
| Publication (2013) |
Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish |
CRISPR-Cas9 |
| Publication (2013) |
Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system |
CRISPR-Cas9 |
| Publication (2013) |
Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System |
CRISPR-Cas9 |
| Publication (2013) |
Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos |
CRISPR-Cas9 |
| Publication (2013) |
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis |
CRISPR-Cas9 |
| Publication (2013) |
Effective gene targeting in rabbits using RNA-guided Cas9 nucleases |
CRISPR-Cas9 |
| Publication (2013) |
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems |
CRISPR-Cas9 |
| Publication (2013) |
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system |
CRISPR-Cas9 |
| Publication (2013) |
Generation of gene-modified mice via Cas9/RNA-mediated gene targeting |
CRISPR-Cas9 |
| Publication (2013) |
Heritable Gene Knockout in Caenorhabditis elegans by Direct Injection of Cas9–sgRNA Ribonucleoproteins |
CRISPR-Cas9 |
| Publication (2013) |
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity |
CRISPR-Cas9 |
| Publication (2013) |
Phylogeny of Cas9 determines functional exchange ability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems |
CRISPR-Cas9 |
| Publication (2013) |
Genotyping with CRISPR-Cas-derived RNA-guided endonucleases |
CRISPR-Cas9 |
| Publication (2013) |
crRNA and tracrRNA guide Cas9-mediated DNA interference in Streptococcus thermophilus |
CRISPR-Cas9 |
| Publication (2013) |
Programmable DNA cleavage in vitro by Cas9 |
CRISPR-Cas9 |
| Publication (2013) |
Genome engineering in cerevisiae using CRISPR-Cas systems |
CRISPR-Cas9 |
| Publication (2013) |
RNA-guided editing of bacterial genomes using CRISPR-Cas systems |
CRISPR-Cas9 |
| Publication (2013) |
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system |
CRISPR-Cas9 |
| Publication (2013) |
Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9 |
CRISPR-Cas9 |
| Publication (2013) |
Targeted genome modification of crop plants using a CRISPR-Cas system |
CRISPR-Cas9 |
| Publication (2013) |
Heritable genome editing in C. elegans via a CRISPR-Cas9 system |
CRISPR-Cas9 |
| Publication (2013) |
CRISPR/Cas9-Targeted Mutagenesis in Caenorhabditis elegans |
CRISPR-Cas9 |
| Publication (2013) |
Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR–Cas9 System |
CRISPR-Cas9 |
| Publication (2013) |
Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease |
CRISPR-Cas9 |
| Publication (2013) |
Multiplex Genome Engineering Using CRISPR/Cas Systems |
CRISPR-Cas9 |
| Publication (2013) |
RNA-programmed genome editing in human cells |
CRISPR-Cas9 |
| Publication (2013) |
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease |
CRISPR-Cas9 |
| Publication (2013) |
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering |
CRISPR-Cas9 |
| Publication (2013) |
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells |
CRISPR-Cas9 |
| Publication (2013) |
DNA targeting specificity of RNA-guided Cas9 nucleases |
CRISPR-Cas9 |
| Publication (2013) |
Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus |
CRISPR-Cas9 |
| Publication (2013) |
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity |
CRISPR-Cas9 |
| Publication (2013) |
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing |
CRISPR-Cas9 |
| Publication (2013) |
Efficient generation of large-scale genome-modified mice using gRNA and Cas9 endonuclease |
CRISPR-Cas9 |
| Publication (2013) |
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity |
CRISPR-Cas9 |
| Publication (2013) |
Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression |
CRISPR-Cas9 |
| Publication (2013) |
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system |
CRISPR-Cas9 |
| Publication (2013) |
CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes |
CRISPR-Cas9 |
| Publication (2013) |
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice |
CRISPR-Cas9 |
| Publication (2013) |
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA |
CRISPR-Cas9 |
| Publication (2013) |
Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis |
CRISPR-Cas9 |
| Publication (2013) |
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems |
CRISPR-Cas9 |
| Publication (2013) |
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. |
TALEN |
| Publication (2012) |
A CRISPR/Cas system mediates bacterial innate immune evasion and virulence |
CRISPR-Cas9 |
| Publication (2012) |
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria |
CRISPR-Cas9 |
| Publication (2012) |
RNA-Guided Human Genome Engineering via Cas9 |
CRISPR-Cas9 |
| Publication (2012) |
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity |
CRISPR-Cas9 |
| Publication (2012) |
Obligate Ligation-Gated Recobmination (ObLiGaRe): Custom-designed nuclease-mdediated targeted integration through nonhomologous end joining |
CRISPR-Cas9 |
| Publication (2011) |
The Streptococcus thermophilus CRISPR/Cas system provides immunity in Eschrichia coli |
CRISPR-Cas9 |
| Publication (2011) |
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III |
CRISPR-Cas9 |
| Publication (2011) |
A TALE nuclease architecture for efficient genome editing |
TALEN |
| Publication (2011) |
Assembly of custom TALE-type DNA binding domains by modular cloning |
TALEN |
| Publication (2011) |
Genetic engineering of human pluripotent cells using TALE nucleases |
TALEN |
| Publication (2011) |
Transcriptional Activators of Human Genes with Programmable DNA-Specificity |
TALEN |
| Publication (2011) |
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting |
TALEN |
| Publication (2011) |
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription |
TALEN |
| Publication (2009) |
Short motif sequences determine the targets of prokarytoic CRISPR defence system |
CRISPR-Cas9 |
| Publication (2009) |
Breaking the code of DNA binding specificity of TAL-type III effectors |
TALEN |
| Publication (2009) |
A simple cipher governs DNA recognition by TAL effectors |
TALEN |
| Publication (2007) |
CRISPR provides acquired resistance against viruses in prokaryotes |
CRISPR-Cas9 |
| Publication (2005) |
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin |
CRISPR-Cas9 |
| Resource guide |
CRISPR-Cas9 Protein for Genome Editing—Getting Started Guide |
CRISPR-Cas9 |
| Resource guide |
Genome Editing Resource Guide |
CRISPR-Cas9, TALEN |
| Tips & tricks |
Top 10 Tips and Tricks: Designing a knock-in experiment |
CRISPR-Cas9, TALEN |
| Tips & tricks |
Top 10 Tips and Tricks: Improve your genomic cleavage detection (GCD) assay |
CRISPR-Cas9, TALEN |
| Tips & tricks |
Top 10 Tips and Tricks: Genome cleavage selection (GCS)–based screening |
CRISPR-Cas9, TALEN |
| Tips & tricks |
Top 10 Tips and Tricks: TAL effector-mediated genome editing |
TALEN |
| Tips & tricks |
Top 10 Tips and Tricks: Successful CRISPR guide RNA synthesis |
CRISPR-Cas9, TALEN |
| Video |
Genome editing video collection |
CRISPR-Cas9 |
| Webinar |
Genome editing webinars |
CRISPR-Cas9, TALEN |
