Succinates and CPG Synthesis Supports

Thermo Scientific DNA Succinates are ideal for the derivatization of controlled pore glass, polystyrene or other supports to use in solid phase oligonucleotide synthesis.

RNA Controlled Pore Glass (CPG) Synthesis Supports are used in the automated synthesis of RNA oligonucleotides (oligoribonucleotides). The CPG support will not swell or shrink and is inert to the reagents used during synthesis. They are offered with a 500Å pore size, ideal for the synthesis of RNA oligonucleotides up to 50 bases in length. 

Custom manufactured and tested, RNA CPG supports can fulfill the specific needs of your oligo application.  

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Bz dA, Bz dC, iBu dG, and T Succinates are formulated as triethylammonium (TEA) salts with standard base protection. Our succinates provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.


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Bz dA Succinate

dC Succinate

iBu dG Succinate

T Succinate

  Bz dA Succinate Bz dC Succinate iBu dG Succinate T Succinate
Cat. No. 27-0030 27-0032 27-0034 27-0036
Chemical name 5′-O-(4,4'-Dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, Triethylammonium salt 5′-O-(4,4'-Dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, Triethylammonium salt 5′-O-(4,4'-Dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, Triethylammonium salt 5′-O-(4,4'-Dimethoxytrityl)-thymidine-3′-succinate, Triethylammonium salt
Formula C48H54N6O9 C47H54N4O10 C45H56N6O10 C43H51N3O10
Molecular weight 859 g/mol 835 g/mol 841g/mol 746 g/mol
HPLC purity ≥ 98.0% ≥ 98.0% ≥ 95.0% ≥ 98.0%
Shipping / Storage condition Ambient / –20 °C
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RNA Ac rC CPG, iPrPAC rG CPG, PAC rA CPG, and rU CPG are provided with 5′DMT and 2′TBDMS protection. Base protecting groups are easily removed under mild cleavage and deprotection conditions. Mild deprotection conditions reduce degradation during final deprotection and allow for incorporation of dyes and other chemical modifications which may be labile under harsh deprotection conditions.


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Ac rC CPG support

iPrPAC rG CPG support

PAC rA CPG support

rU CPG support

  Ac rC CPG support iPrPAC rG CPG support PAC rA CPG support rU CPG support
Cat. No. SY6505 SY6506 SY6503 SY6504
Description 5′-O-(4,4′-Dimethoxytrityl)-N4-(acetyl)-2′-O-t-butyldimethylsilyl-Cytidine-3′-O-long chain alkyl amine controlled pore glass 5′-O-(4,4′-Dimethoxytrityl)-N2-(isopropylphenoxyacetyl)-2′-O-t-butyldimethylsilyl-Guanosine-3′-O-long chain alkyl amine controlled pore glass 5′-O-(4,4′-Dimethoxytrityl)-N6-(phenoxyacetyl)-2′-O-t-butyldimethylsilyl-adenosine-3′-O-long chain alkyl amine controlled pore glass 5′-O-(4,4′-Dimethoxytrityl)-2′-O-t-butyldimethylsilyl-uridine-3′-O-long chain alkyl amine controlled pore glass
Pore size 500 Å
Loading 40 ± 5 µmol/g
Identity Confirmation of base identity by UV analysis
Shipping / Storage conditions Ambient / –20 °C
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Process and supply chain control

  • A controlled raw material supply chain and established vendor partnerships ensure consistency and security of supply
  • All DNA succinates are supplied with lot-specific quality control data including HPLC analyses
  • Processes are monitored from material procurement through final QC and product release under updated ISO9001:2015 standards, providing batch-to-batch reproducibility

Product configurations

  • Base modified CPG supports are available in a variety of pore sizes: 500 Å, 1000 Å, etc. Contact us to learn more

Custom services

  • Custom manufacturing services are available to assist you in your development or scale-up of succinates and synthesis supports, as well as selecting your preferred base and/or sugar modifications

Flexible packaging

  • Common oligo synthesizer pack sizes are available for immediate delivery
  • Custom and bulk packaging are also available. Contact us to learn more

 

Not finding what you are looking for? We also offer DNA phosphoramiditesRNA phosphoramiditesspecialty phosphoramiditesdye-labeled phosphoramidites2′-modifications, and linker and spacer phosphoramiditesContact us to learn more.

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