We offer strong cation exchange (SCX) and strong anion exchange (SAX) resins and membranes. Our ion exchange (IEX) resins are rigid polymeric beads with covalent surface chemistries, which enable easier handling and packing while offering superior physical and chemical stability—resulting in a robust manufacturing process.

POROS™ XS Strong Cation Exchange Resin and the POROS™ XQ Strong Anion Exchange Resin combine high binding capacity with a salt tolerance of up to 150 mM NaCl. The POROS™ HQ 50 µm Strong Anion Exchange Resin contains a quaternized polyethyleneimine functional group, yielding a high capacity, and is composed of a Perfusion Chromatography™ media designed for the separation and purification of biomolecules. These resins deliver unprecedented separation capability.

Pierce™ strong cation and anion exchange spin columns are membrane-based spin formats that eliminate the need for column packing, allow multiple samples to be processed simultaneously, and are ideal for working with low-volume buffer solutions.

Key features of our ion exchange chromatography products

  • High performance—resins and membranes are designed to maximize resolution and protein yield 
  • Robust—POROS resins offer a polystyrene-divinylbenzene backbone with a large through-pore structure, enabling higher capacity and salt tolerance from low to high sample volumes
  • Scalable—POROS resins are optimized for low to high flow rates using FPLC (1,000–5,000 cm/hr), providing a seamless transition from small-scale to process-scale purification
  • Multiple formats—membrane- and resin-based formats allow flexibility between small– and large–sample volume purification
  • Economical—pricing is similar to or better than our leading competitors

Choose the right ion exchange (IEX) chromatography product

Product links in the last row of each column

  Pierce (SCX)
Spin Columns
POROS XS
Resin
Pierce (SAX)
Spin Columns
POROS XQ
Resin
POROS 50 HQ
Resin
Surface charge Strong cation exchange (SCX) Strong cation exchange (SCX) Strong anion exchange (SAX) Strong anion exchange (SAX) Strong anion exchange (SAX)
Format membrane resin membrane resin resin
Binding capacity 4 mg (Mini)
60–80 mg (Maxi)
>100 mg/mL (dynamic) N/A >140 mg/mL (dynamic) 60–70 mg/mL (dynamic)
Salt tolerance ≤25 mM 150 mM ≤25 mM ≤50 mM ≤150 mM
Recommended processing volumes 0.5 mL (Mini)
20 mL (Maxi)
10 mL–1000 L 0.5 mL (Mini)
20 mL (Maxi)
10 mL–1000 L 10 mL–1000 L
Packaging options 0.5 mL spin columns (Mini)
20 mL spin columns (Maxi)
loose resin 0.5 mL spin columns (Mini)
20 mL spin columns (Maxi)
loose resin loose resin
Order product(s) 90008 (0.5 mL)
90009 (20 mL)
82071 90010 (0.5 mL)
90011 (20 mL)
82073 82077

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