Using Ion AmpliSeq™ targeted sequencing technology, thousands of amplicons, including the complete exome, can be rapidly amplified by PCR and subsequently sequenced using the Ion S5™ and Ion S5™ XL Systems. To get started, choose a sequencing application from the following table and download the appropriate user guide for the step you are interested in.

Sequencing workflow for inherited disease research

Working with RNA? See RNA analysis with the Ion S5 System

Documents and resources


User guides and FAQs


Learn more

Training, events, and webinars