Analyzing Halides by Ion Chromatography

Ion chromatography—the ideal method for halide analyses

Halides are binary compounds formed by combining a metal with one of the five halogen elements (chlorine, bromine, fluorine, iodine, and astatine). Many of these compounds will dissolve in water, and because of this solubility, they usually occur only under special conditions. The most common halide compound is sodium chloride (NaCl), also known as rock salt.

Halide analysis

Compared to standard wet chemical techniques, ion chromatography (IC) offers improved speed and accuracy for halide analysis. Using suppressed conductivity lowers the background conductivity caused by the eluent and effectively increases the conductivity of the analyte. Common inorganic anions such as fluoride, chloride, bromide, and sulfate can be resolved in the same injection, as well as common organic anions.

Regulatory information

  • The FDA recommends 150 micrograms of iodine per day, its primary source being iodized table salt.
  • The U.S. Pharmacopeia (USP) monograph for adenosine has assays to determine the amounts of chloride and sulfate in adenosine. The acceptance criterion is that the sample solution is not more than 0.007% chloride.

Example application notes