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A Guide for Proper Cryogenic Storage

To ensure reproducible results and continuity in research and biomedical processes, today’s scientists are faced with the task of genetically stabilizing replicable materials such as living cells and organisms, and ensuring sub-cellular components such as nucleic acids and proteins are preserved unchanged.

Proven Solutions to Preserve Samples

Sample storage at cryogenic and extremely low temperatures provides security for biological specimens and derivatives of those specimens, genomic material, and compounds over extended periods of time. Because of the valuable or irreplaceable nature of these samples being stored, it is critical to ensure that they are adequately protected from the harsh storage environment and during handling processes. 

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Type Title
Application brief  Thermo Scientific Nautilus LIMS: Delivering Data Management and Workflow Solutions for Genomics, Clinical Diagnostics and Biorepository Laboratories
Application note  Cryopreservation of mammalian cells—protocols
Application note  Detection of cellular response to an in vitro challenge with bacterial gram-negative lipopolysaccharides (lps) in peripheral blood mononuclear cells (PBMCs) for biomarker research
Application note  Essential lipidomics experiments using the LTQ Orbitrap Hybrid Mass Spectrometer
Application note  Improving label-free quantification of plasma and serum proteins using a high-resolution Hybrid Orbitrap Mass Spectrometer
Application note  Metabolite profiling and identification employing high resolution MS strategies and dedicated software
Application note  Metabolomics strategies using GC-MS/MS Technology
Application note  Selected-reaction monitoring-mass spectrometric immunoassay analysis of parathyroid hormone and related variants
Application note  Targeted kinase inhibitor profiling using a Hybrid Quadrupole-Orbitrap Mass Spectrometer
Article  Advancing the Lab? Look to LIMS
Article  Effectively storing and analyzing biological data at UK Biobank
Article  Laying the foundation for next-gen cancer diagnostics
Article  Metabolomic profiling of anionic metabolites in head and neck cancer cells by capillary ion chromatography with Orbitrap Mass Spectrometry
Article  Storing and tracking samples
Article  The LIMS effect
Blog  Fisher BioServices Blog
Blog  Inside Biobanking
Brochure  Automated sample storage resource guide
Brochure  Biobanking and biospecimen management with the Thermo Scientific Nautilus LIMS
Brochure  Cryopreservation equipment
Brochure  KingFisher Automatic Purification systems
Brochure  New mass spectrometry tools to transform metabolomics and lipidomics
Brochure  Purification of high-quality RNA from cell samples
Brochure  Rapid and reproducible DNA isolation from 1 ml of whole blood
Brochure  Targeted protein quantification with high-resolution, accurate-mass MS
eBook  Protecting Your Protocol: Operating a Flawless Clinical Agent Repository
eBook  Standardizing Biosample Management: Why Use Collection Kits
Handbook  A Guide for Proper Cryogenic Preservation
Handbook  Quantitative Proteomics Handbook
Handbook Mass Spectrometry Sample Preparation Handbook
Poster  A novel low-volume high-density system for sample storage
Poster  Analysis of whole lipid extracts using on-line high resolution LC-MS
Poster  Biobank storage temperatures: An illustrative guide
Poster  Towards a universal LC/MS method for metabolomics
Technical note  Can 2D barcoded tubes resist DMSO?
Training module  Sample Inventory: How do I maintain sample integrity during an inventory process?
Training module  Sample Inventory: How to maintain sample integrity
Training module  Sample Inventory: What do I need to know before opening the door?
Webinar  Laboratory processing, automation, analysis for biobank samples
Webinar  Qualification and validation webinar: How to manage cold chain qualification when handling high-value biologics
Webinar  The seven keys to safeguarding your cryopreserved cells
White paper  Controlled-rate freezing of cells during ultra cold transit