Vanquish Flex UHPLC Systems

Easier method development and routine analysis

For assays that require more flexibility to accommodate all applications, the Thermo Scientific Vanquish Flex UHPLC systems enable you to increase your productivity and drive innovation without compromising quality. Whether you need an LC or LC-MS solution, the flexibility of the Vanquish Flex systems with binary or quaternary solvent blending provides the most advanced performance through better separations, more results and easier interaction.

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New benchmarks in accuracy, precision, and sensitivity

As a member of the Vanquish UHPLC product line, the Vanquish Flex Binary UHPLC system and Vanquish Flex Quaternary UHPLC system share all Vanquish-inherent values, such as a design focus on uptime, robustness and reliability. The Vanquish Flex systems provide:

  • Unsurpassed retention time and peak area precision
  • Highest detector sensitivity and lowest baseline noise
  • Less maintenance and easy set-up with Thermo Scientific Viper fingertight fittings
  • Dedicated solutions for exceptional LC-MS performance

Also benefit from the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Flex UHPLC systems to other manufacturers' chromatography data systems.

Choose from two Vanquish Flex UHPLC systems

  • Biocompatible with a state-of-the-art binary high-pressure pump and state-of-the-art binary solvent blending
  • Ideal for extended throughput that can be seamlessly coupled to a mass spectrometer (MS).
  • A biocompatible UHPLC system with state-of-the-art low-pressure quaternary solvent blending.
  • Ideal for pharmaceutical and biopharmaceutical applications.

Also benefit from the industry-leading, easy-to-use Thermo Scientific Chromeleon CDS software with eWorkflow method setup, dedicated ePanels, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Horizon UHPLC system to other manufacturers' chromatography data systems.

Chromatography columns and consumables

Find the right solutions for your workflow and achieve better separations. Choose from more than 4,000 products across sample preparation and handling through to columns, including products bundles specifically selected for use with Thermo Scientific Vanquish UHPLC systems.

Overview of the Vanquish UHPLC systems

    Vanquish Flex
Binary UHPLC System
Vanquish Flex Quaternary UHPLC System
  Solvent blending High pressure binary solvent blending for fast and reliable UHPLC Low pressure quaternary solvent blending for flexible method development
Performance System pressure
Up to 1000 bar
Retention time precision
Flow range
0 – 8 mL/min
System Features Design Modular Modular
SmartInject technology for unsurpassed retention time precision    
SmartFlow technology for excellent flow precision    
Pump High-pressure gradient proportioning Low-pressure gradient proportioning
Active and passive pre-heating    
Multi-mode column thermostatting    
Sample cooling  
Temperature range: 4 – 40 °C
Temperature range: 4 – 40 °C
System components Pump Vanquish Binary Pump F
UHPLC performance for demanding routine application up to 1000 bar
Vanquish Quaternary Pump F
UHPLC performance with more solvent flexibility up to 1000 bar
Autosampler Vanquish Split Sampler FT
For applications up to 1000 bar
Extended sample capacity Vanquish Charger (optional)
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management.
Column compartment Vanquish Column Compartment
Provides two column thermostatting modes (still and forced air), active and passive solvent pre-conditioning and post-column cooling for optimized control of your separations and advanced method transfer.
  Virtually zero dead volume system connections Viper UHPLC Fittings Kits
Order all the UHPLC fittings and capillaries you need for your system or application in a single kit
= Not applicable = Poor = Good = Better = Best

Compatible components for all Vanquish UHPLC systems

Detector options Vanquish columns Chromeleon CDS
Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before.
All Vanquish systems can be used with any of our HPLC and UHPLC columns
  • Streamlines your data processing
  • Industry-leading ease of use and intelligent functionalities
  • Outstanding data integrity
  • Unique user guidance and hardware automation features designed for Vanquish systems

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Interact with Vanquish

Take a virtual tour of the Vanquish and see how each module’s advanced technology will separate your science from the status quo.

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