Vanquish Horizon UHPLC Systems

Deliver results without compromise

Today’s scientists solve various challenges needed to produce life-saving medicines, improve the quality of our food and the environment, and discover the next breakthrough in science. Built from the ground up, the Thermo Scientific Vanquish Horizon UHPLC System is our premier UHPLC system to help solve these challenges. It delivers more and better results with superior separations and easier interaction with no trade-offs in performance, robustness, or ease-of-use. This fully integrated and biocompatible system features high sample capacity for high-throughput workflows, industry-leading pumping performance, amazingly high signal-to-noise (S/N) and linearity, two-mode thermostatting, and more.

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Setting new standards in UHPLC

This integrated, fully biocompatible system provides you with unrivaled performance and throughput for applications requiring high-end UHPLC.

  • Unsurpassed retention time and peak area precision
  • Highest detector sensitivity and lower baseline noise
  • Less maintenance and easy set-up with Thermo Scientific Viper Fingertight Fittings
  • Dedicated solutions for exceptional LC-MS performance

Also benefit from the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Horizon UHPLC system to other manufacturers' chromatography data systems.

Chromatography columns and consumables

Find the right solutions for your workflow and achieve better separations. Choose from more than 4,000 products across sample preparation and handling through to columns, including products bundles specifically selected for use with Thermo Scientific Vanquish UHPLC systems.


Overview of the Vanquish Horizon UHPLC system

    Vanquish Horizon UHPLC System
Performance System pressure
Up to 1500 bar
Retention time precision
Flow range
0 – 5 mL/min
Biocompatibility  
System Features Design Modular
SmartInject technology for unsurpassed retention time precision  
SmartFlow technology for excellent flow precision  
Pump High-pressure gradient proportioning
Active and passive solvent pre-heating  
Multi-mode column thermostatting  
Sample cooling  
Temperature range: 4 – 40 °C
System components Pump Vanquish Binary Pump H
The pump with the highest backpressure at 1500 bar; ideal for any gradient performance, from shallow to ballistic
Autosampler Vanquish Split Sampler HT
Excellent precision, accuracy, and short cycle times with innovative air-stream cooling and barcode reading for inventory management for all workflows up to 1500 bar
Extended sample capacity Vanquish Charger (optional)
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management.
Column compartment Vanquish Column Compartment
Provides two column thermostatting modes (still and forced air), active and passive solvent pre-conditioning and post-column cooling for optimized control of your separations and advanced method transfer.
Virtually zero dead volume system connections Viper UHPLC Fittings Kits
Order all the UHPLC fittings and capillaries you need for your system or application in a single kit
= Not applicable = Poor = Good = Better = Best

Compatible components for all Vanquish UHPLC systems

Detector options Vanquish columns Chromeleon CDS
Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before.
All Vanquish systems can be used with any of our HPLC and UHPLC columns
  • Streamlines your data processing
  • Industry-leading ease of use and intelligent functionalities
  • Outstanding data integrity
  • Unique user guidance and hardware automation features designed for Vanquish systems

Discover the best HPLC systems for your applications and budget

Discover the best HPLC system for your applications and budget

Use these 2 tools to help you decide

HPLC Systems Selection Guide
Use this tool to rank the top HPLC instruments for your applications based on your responses to simple pull-down menus.

HPLC System Total Cost of Ownership Calculator
Use this tool to estimate your cost for purchasing and running Thermo Scientific HPLC and UHPLC systems. You can compare costs between instruments.


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Interact with Vanquish

Interact with Vanquish

Take a virtual tour of the Vanquish and see how each module’s advanced technology will separate your science from the status quo.

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