The proteasome is a large multi-protein complex that serves to degrade damaged or unneeded proteins in a cell by proteolysis. Every proteasome is made up of four stacked rings that form a central core where proteins are degraded. Each of the four rings contains seven subunits. The two inner rings consist of seven beta subunits that are primarily catalytic. The two outer rings are made up of seven alpha subunits which form the entrance to the core. These alpha subunits are structural and function as a gate to block unregulated entrance to the interior. They also contain docking domains for regulatory particles.
Proteasomal degradation is critical to many cellular processes including cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
Proteasome marker antibodies detect proteins specific to the proteasome and can aid in the study of the structure and dynamics of the proteasome. Proteasome marker antibodies can also help elucidate the role or roles a protein may play in a number of tasks that are centered in or influenced by the proteasomes. Quality Invitrogen proteasome marker antibodies are available for a variety of research needs.