Custom-Affinity-Ligand-and-Resin-Development
CaptureSelect purification products enable the efficient capture of therapeutic proteins from any feed stream, thereby helping reduce the number of process steps, increase yield, as well as provide a platform approach for purifying any target biotherapeutic.

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We offer a unique service for the development of product- and/or process-specific affinity solutions tailored to a target protein and its specific requirements.

The custom ligand can be immobilized on a variety of backbones, including POROS resins, and further developed into an affinity resin, which can be used in large-scale processing of biopharmaceuticals.

Custom CaptureSelect resin development program

Library construction
1 to 10 targets


Lead
screening
200 → 24 → 6

Ligand screen:

  • Specificity
  • Binding kinetics
  • Mild elution
  • Stability

 

Prototype
resin testing
6 → 2

Prototype screen:

  • Ligand scalability
  • One-step purity with feedstock
  • Elution profiles
  • Ligand stability

 

Lead
selection
2 → 1

Lead testing:

  • Larger scale production of lead prototypes
  • Resin evaluation under process conditions

 

cGMP
suitable resin


Final resin:

  • Process validation
  • Leakage ELISA
  • Regulatory support file

 

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No matter what your development challenges are, we are here to help. Our experienced team of scientists and technical specialists is ready to assist you with custom application solution. Complete this form to start the conversation and move towards a custom solution designed just for you. 

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Start from existing candidates in our pipeline

Through our library development process we have identified a number of candidates that may serve as excellent starting points for a custom affinity resin program. Pipeline opportunities include:

Table 1. CaptureSelect affinity products for purification

Product Stage

Therapeutic Proteins

Viruses

Antibody Types

Research scale purification resins

Antithrombin III (ATIII)
Fibrinogen (Factor I)
Transferrin (TF)
Apolipoprotein H (ApoH)
C1-inhibitor (C1-Inh)
Granulocyte-macrophage colony-stimulating factor (GM-CSF)

Adenovirus (Adv5)

IgA (Fc)
IgA-CH1
IgM
IgE
Bovine IgA
Rabbit IgG (Fc)

Lead Selection

Prothrombin (Factor II)
Deoxyribonuclease (DNAse)

Influenza (HA)

IgG-Fc (mouse)

Prototype resin testing

Universal affinity tag (Uni-Tag)
Factor X

Baculovirus

 

Lead Screening

Interferon alpha and beta (IFNalpha/beta)
Interleukin 2 (hIL2)
Factor V, FXI, FXII, FXIII, and FH
Erythropoietin (EPO)

Exosomes
Lentivirus (VSV-G)

scFv / human VH
IgY

Library Construction

CHO host cell proteins

 

IgG-Fc (rat)

Technical resources and literature

Posters:

Scientific publications:

Bioprocessing resources

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Support

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For Research Use or Further Manufacturing. Not for diagnostic use or direct administration in to humans or animals.