Liquid Biopsy Presentations and Case Studies

Liquid biopsy has been gaining traction within cancer research as a complementary or alternative technique to solid tissue biopsy due to a few factors:

  • Less invasive procedure enabling sampling at multiple time points to monitor progression of the cancer
  • Better representation of tumor heterogeneity
  • Faster turnaround time from sample to results
  • Lower costs compared with traditional tissue biopsies

Hear what your peers are doing in liquid biopsy through the testimonials, videos, case studies, and more below. 

Video: Variant detection in cell-free DNA from NSCLC using NGS

Dr. Tracy Stockley; Associate Director, Molecular Diagnostics Division; Princess Margaret Cancer Center

  • Dr. Tracy Stockley presents the utilization of NGS and cell-free DNA for detection of EGFR T790M resistance mutation
  • Focuses on mutation detection in cell-free DNA and comparison with droplet digital PCR technology
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Testimonials

Detection of rare mutations like EGFR T790M down to 0.14% AF

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“Using the Oncomine Lung cfDNA Assay, we were able to amplify more difficult samples.  The assay allowed us the detection of mutations like EGFR T790M down to 0.14% allelic fraction.”

—Dr. Jose Luis Costa, Senior Researcher, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal

Detection of genomic heterogeneity in metastatic colorectal cancer samples

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“Genomic heterogeneity after anti-EGFR therapy was successfully detected in 94% of the research metastatic colorectal cancer samples using a next-generation sequencing multibiomarker approach. The Oncomine Colon cfDNA Assay enabled detection of somatic mutations with MAF >0.1%.”

—Dr. Bea Bellosillo, Head of Section, Hospital del Mar, Spain


Case studies

An international multi-center study evaluates use of cfDNA for tracking tumor heterogeneity and evolution in lung cancer

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  • Dr. Nicola Normanno presents the results of an international multi-center study
  • Focuses on tumor heterogeneity and evolution that could change treatment decisions in the future

Mutational analysis of cfDNA in a lung tumor

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  • Dr. José Luis Costa presents data obtained running cfDNA from plasma samples on the Ion S5 System
  • Focuses on expected results from a research study monitoring a lung tumor