Transcription activator–like effector nuclease (TAL, TALE, or TALEN) proteins are naturally occurring transcriptional activators secreted by Xanthomonas spp. into their plant hosts. The deciphering of the TAL effector “code” led to the engineering of designer TAL effector proteins, a new approach to genome editing. Whether through targeted nucleases for genome engineering, or by precisely directed moderators of gene expression, GeneArt® Precision TALs are already helping advance a broad range of life science applications, including cell, molecular, and synthetic biology; drug discovery; and biofuels research.
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Design with precision
GeneArt® Precision TALs provide a custom DNA-binding proteins for accurate DNA targeting and precise genome editing. Unlike other technologies that limit the choice of targets, or provide ambiguous results, GeneArt® Precision TAL enables the targeting of any locus in the genome. GeneArt® Precision TALs offers site-specific delivery of nucleases, activators, repressors, chromatin modifiers, genomic labels, and cross-linking molecules. This genome editing technology is known to function in a variety of host systems, including bacteria, yeast, plants, insects, zebrafish, and mammals.
For Research Use Only. Not for human or animal therapeutic or diagnostic use