SimpliAmp Thermal Cycler

Elegant design, smart choice—
now cloud-enabled for secure remote access

The Applied Biosystems SimpliAmp Thermal Cycler is an easy-to use, compact, and accurate thermal cycler designed to fit every lab’s essential PCR workflow. Innovations like a responsive color touch screen and Applied Biosystems VeriFlex temperature control technology enable simple, accurate optimization. And now you can access your SimpliAmp cycler with Thermo Fisher Connect, giving you the freedom to design and securely upload your methods from any mobile device or desktop computer.

For limited time, get 3 year warranty with SimpliAmp Thermal Cycler purchase ›

   Request a demo

Instrument tour

Simple, intuitive touch screen and simulation modes

The SimpliAmp Thermal Cycler has a large color graphical user interface for easy programming and quick checks of your run status at the bench. Simulation modes now make the transition from previous thermal cyclers to the SimpliAmp Thermal Cycler simple, accurate, and efficient.

See what your colleagues are saying about the SimpliAmp Thermal Cycler

Precise PCR optimization with VeriFlex technology

Applied Biosystems VeriFlex Blocks provide a better-than-gradient approach to PCR optimization. With three separate Peltier blocks, you have precise control over three temperature zones.

  • Enable highly accurate determination of optimal annealing temperatures
  • Help eliminate guesswork often associated with standard gradient cyclers
  • Help save time by running up to three reactions with different annealing temperatures in the same PCR run
  • Use your thermal cycler as an incubator; take advantage of precision temperature control

Boost productivity with secure remote access to your SimpliAmp Thermal Cycler

SimpliAmp is a cloud-enabled instrument, allowing you secure, private access with a Thermo Fisher Connect account. Design and share protocols and monitor your runs from anywhere, anytime with any mobile device or desktop computer.

View quick setup ›

Download the Remote Access User Guide ›

Store Store

Design protocols from anywhere, store in the cloud.

Develop protocols on any desktop computer or mobile device and store them in your secure personal cloud account. When you are ready to prepare your run, simply access your cloud account from your SimpliAmp.

iPhone scrolled

Store Monitor

Remote monitoring of runs in real-time.

Download our Instrument Connect remote monitoring app to see availability, run progress, catch issues while they are in progress, and more on your SimpliAmp from anywhere, anytime.

Store Share

Discretionary access to project folders and protocols.

Share your protocols or other files with other Thermo Fisher Connect users on campus and around the world. It’s easy, convenient, and protected by the highest levels of privacy standards.


 Learn more about Thermo Fisher Connect ›

For peace of mind, the Thermo Fisher Cloud has high industry-standard security, so your work remains secure. We have partnered with Amazon Web Services (AWS) to offer a robust platform.

Manuals and specifications

Application notes

Applied Biosystems PCR plastics

Applied Biosystems plastic consumables offer excellent PCR and qPCR performance in formats developed to meet your experimental needs. All of our plastic consumables are validated with Applied Biosystems instruments for optimal fit and performance. Consistent, precise results.


Applied Biosystems Thermal Cycler, Plastics and Services Brochure

PCR and cDNA Synthesis Support Center 
Tips and troubleshooting help

School of Molecular Biology, PCR Education
Technical content for new and experienced molecular biologists

Thermal Cycler Software and Firmware Files
Download the latest updates for your instrument

Interested in private label thermal cyclers?
Submit an inquiry


We provide award-winning service options for all Applied Biosystems thermal cyclers.

Service plans

  • Rapid Exchange minimizes interruptions from unplanned instrument downtime
  • Global Repair Center provides a cost-efficient way to maximize uptime and achieve superior performance


Additional services available

Instrument qualification service: Have one of our engineers perform temperature qualifications at your site. You may also contact Instrument Services to purchase a temperature verification tool and perform the qualification yourself.