Accurate high-throughput sequencing

The Ion Proton System reduces the high cost and complexity of high-throughput sequencing, bringing it to your lab on your schedule.


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Ion Proton System designed for high-throughput
sequencing of exomes, transcriptomes and genomes

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Ion Torrent™ next-gen sequencing technology

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Affordable sequencing for all

The Ion Proton System has been designed with affordability in mind. The system combines semiconductor sequencing technology with biochemistry to directly translate chemical information into digital data. This eliminates the need for expensive optics and complex sequencing chemistries, resulting in a sequencing system that is highly-affordable to own and operate.

Scalable, flexible throughput

Chip-based semiconductor sequencing enables you to scale your runs to your research needs. The Ion PI™ Chip provides you with 40–80 M reads, enabling you to sequence 1–3 human exomes or 1–8 human transcriptomes per run.


Fast, simple workflows

The Ion Proton System offers a complete workflow from sample through analysis, and variant calling or RNA analysis. It may be used with the Ion Chef System to enable automated, high-throughput template preparation and reproducible chip loading. See Proton configurations for more details. Built for speed, the Ion Proton System provides fast sequencing run times, taking you from DNA to variants in a single day. It is equipped with Ion Reporter Software, providing integrated tools for tertiary data analysis for DNA variation analysis across single, paired, or trio research samples.

Select targets

When you have between ~20 and ~1,000 targets, next-generation sequencing enables fast, economical genetic sequencing from DNA and RNA.

Construct library

Ion Torrent library kits enable simple, high-performance library solutions for exome, transcriptome, and genome sequencing that are optimized for use with Ion semiconductor sequencing systems.

Prepare template

The Ion Chef System achieves high-throughput automated template preparation and chip loading for users of almost any level of expertise. Lower-throughput labs can choose the Ion OneTouch 2 System, for automated template preparation.

Run sequence

The Ion Proton System is ideal for sequencing transcriptomes and exomes. The sequencing run time is only 4 hours, enabling the entire workflow from library to primary data analysis results in under 24 hours. Torrent Suite Software offers simple run setup using predesigned workflows and run monitoring in real-time.

Analyze data

Integrate, annotate and interpret your DNA variants faster and more easily using Ion Reporter Software, available in the cloud or on a local server.