Increase Your Versatility with Orbitrap Fusion Lumos Upgrades

Achieve even more with the Orbitrap Fusion Lumos Tribrid Mass Spectrometer

The Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer is the most advanced mass spectrometry system that can be upgraded to even higher resolution (1M), additional dissociation capabilities (UVPD and ETD), and a unique internal calibration (IC).

UV Photodissociation (UVPD)

UV Photodissociation (UVPD)

Achieve unambiguous characterization of lipids, modified peptides and intact proteins, even in complex mixtures, and obtain unique structurally diagnostic information (e.g., double bonds) that cannot be obtained with CID, HCD, ETD or EThcD. UVPD enhances unique sequence coverage over 20%, generating MSn fragments in the linear ion trap that can be detected by either the ion trap or Orbitrap mass analyzer.

Videos

Testimonial

Testimonial

Testimonial


Testimonial

Testimonial


UVPD complements current fragmentation technologies, providing over 20% unique sequence coverage for comprehensive characterization of molecular species. These MSn fragments, which are generated in the linear ion trap, can be detected by either the ion trap or the Orbitrap mass analyzer. See how in this animation.


ASMS 2017 presentations and posters

Download links available soon

Presentations

  • Top-down HDX Analysis of Proteins Using Ultraviolet Photodissociation. Brodie N et al.
  • Extension of Orbitrap Capabilities to Enable New Applications. Makarov A et al.
  • Single Amino Acid Resolution of Glycosites with Top-Down UVPD of Glycoproteins. Going C et al.
  • Precise Structural Characterization of Unsaturated Lipids by 213 nm UV Photodissociation MSn. Reid G et al.
     

Posters

1 million (M) resolution

1 Million (M) resolution

Resolve isobaric components, obtain fine isotope information, and achieve confident assignment of the elemental composition of small molecule analytes with the ultra-high 1 Million (1M) resolution setting of the Orbitrap Fusion Lumos Tribrid Mass Spectrometer. The 1M resolution option significantly aids the characterization and quantitation of structurally diverse targets.

Videos

Testimonial

Animation

Testimonial


ASMS 2017 presentations and posters

Download links available soon

Presentations

  • Extension of Orbitrap Capabilities to Enable New Applications. Makarov A et al.
  • Resolution of 13C and Deuterium Isotopes Allows Lipid Fluxomics Analysis By Rate of Deuterium Incorporation; Mitsche M et al.
  • High Resolution Approaches for the Identification of Environmental Metabolites. Gilbert J et al.

Posters

Easy-ETD

Easy-ETD

Experience enhanced resolution of peptides and proteins with Easy-ETD, which introduces electron transfer dissociation using Townsend discharge ionization to create a highly stable reagent ion flux- yet is compact enough to fit behind the ion funnel. ETD and EThcD high collision disocciation (HD) modes are available on the Orbitrap Fusion Lumos Tribrid MS and increase detection limits and dynamic range of ETD spectra.

Flying ion motion path of the Orbitrap Fusion Lumos MS. Enhancements are shown close-up, facilitated by the High Capacity Transfer Tube, Electrodynamic Ion Funnel, Advanced Quadrupole Technology, Advanced Vacuum Technology and ETD HD dissociation.

Easy-IC

Easy-IC

Improve mass-to-charge (m/z) ratio assignment accuracy to under 1 ppm with Easy-IC, which incorporates a second ion source that delivers a regulated number of calibrant ions into the analyte ions. This feature enables real-time fine adjustment of the instrument's m/z calibration, correcting otherwise uncompensated errors due to temperature fluctuations and scan-to-scan variations.

UV Photodissociation (UVPD)

UV Photodissociation (UVPD)

Achieve unambiguous characterization of lipids, modified peptides and intact proteins, even in complex mixtures, and obtain unique structurally diagnostic information (e.g., double bonds) that cannot be obtained with CID, HCD, ETD or EThcD. UVPD enhances unique sequence coverage over 20%, generating MSn fragments in the linear ion trap that can be detected by either the ion trap or Orbitrap mass analyzer.

Videos

Testimonial

Testimonial

Testimonial


Testimonial

Testimonial


UVPD complements current fragmentation technologies, providing over 20% unique sequence coverage for comprehensive characterization of molecular species. These MSn fragments, which are generated in the linear ion trap, can be detected by either the ion trap or the Orbitrap mass analyzer. See how in this animation.


ASMS 2017 presentations and posters

Download links available soon

Presentations

  • Top-down HDX Analysis of Proteins Using Ultraviolet Photodissociation. Brodie N et al.
  • Extension of Orbitrap Capabilities to Enable New Applications. Makarov A et al.
  • Single Amino Acid Resolution of Glycosites with Top-Down UVPD of Glycoproteins. Going C et al.
  • Precise Structural Characterization of Unsaturated Lipids by 213 nm UV Photodissociation MSn. Reid G et al.
     

Posters

1 million (M) resolution

1 Million (M) resolution

Resolve isobaric components, obtain fine isotope information, and achieve confident assignment of the elemental composition of small molecule analytes with the ultra-high 1 Million (1M) resolution setting of the Orbitrap Fusion Lumos Tribrid Mass Spectrometer. The 1M resolution option significantly aids the characterization and quantitation of structurally diverse targets.

Videos

Testimonial

Animation

Testimonial


ASMS 2017 presentations and posters

Download links available soon

Presentations

  • Extension of Orbitrap Capabilities to Enable New Applications. Makarov A et al.
  • Resolution of 13C and Deuterium Isotopes Allows Lipid Fluxomics Analysis By Rate of Deuterium Incorporation; Mitsche M et al.
  • High Resolution Approaches for the Identification of Environmental Metabolites. Gilbert J et al.

Posters

Easy-ETD

Easy-ETD

Experience enhanced resolution of peptides and proteins with Easy-ETD, which introduces electron transfer dissociation using Townsend discharge ionization to create a highly stable reagent ion flux- yet is compact enough to fit behind the ion funnel. ETD and EThcD high collision disocciation (HD) modes are available on the Orbitrap Fusion Lumos Tribrid MS and increase detection limits and dynamic range of ETD spectra.

Flying ion motion path of the Orbitrap Fusion Lumos MS. Enhancements are shown close-up, facilitated by the High Capacity Transfer Tube, Electrodynamic Ion Funnel, Advanced Quadrupole Technology, Advanced Vacuum Technology and ETD HD dissociation.

Easy-IC

Easy-IC

Improve mass-to-charge (m/z) ratio assignment accuracy to under 1 ppm with Easy-IC, which incorporates a second ion source that delivers a regulated number of calibrant ions into the analyte ions. This feature enables real-time fine adjustment of the instrument's m/z calibration, correcting otherwise uncompensated errors due to temperature fluctuations and scan-to-scan variations.