LanthaScreen cellular assays are developed to ensure proper pharmacology toward the target of interest.  Each assay provides excellent response profiles, yields a Z´-factor above 0.6, and demonstrates the appropriate EC50/IC50 responses to known agonists or antagonists.  In addition, the cell lines used in LanthaScreen cellular assays are mycoplasma-negative and tested for optimal performance under a variety of experimental conditions.  Our goal is to provide effective tools with robust results to keep your screening program on track.

See the list of available LanthaScreen cellular assays below, along with validation data and assay protocols specific to detection of each post-translational modification.

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Target Substrate Modification Detected Cell Line Name Cell Line Cat.# Antibody Validation Packet Customer Protocol
AKT Phosphorylation of Ser473 LanthaScreen AKT HEK293E K1615 LanthaScreen Tb-anti-AKT [pSer473] Antibody
ATF2 (19-106) Phosphorylation of Thr71 LanthaScreen ATF2 (19-106) A549 K1679B LanthaScreen Tb-anti-ATF2 [pThr71] Antibody
c-Jun (1-79) Phosphorylation of Ser73 LanthaScreen c-Jun (1-79) HeLa K1680 LanthaScreen Tb-anti-c-Jun [pSer73] Antibody
ERK2 Phosphorylation of Thr185/Tyr187 LanthaScreen ERK2 U2OS K1587 LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody
ERK2 Phosphorylation of Thr185/Tyr187 LanthaScreen ERK2 A375 (B-RAF V600E) K1798 LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody
IGF-1R Phosphorylation of Tyr Residues LanthaScreen IGF-1R GripTite K1834 LanthaScreen Tb-PY20 Antibody
IkB Phosphorylation of Ser32 LanthaScreen IkB GripTite K1681B LanthaScreen Tb-anti-pIkB [pSer32] Antibody
PDCD4 Phosphorylation of Ser457 LanthaScreen PDCD4 HEK293E K1593 LanthaScreen Tb-anti-PDCD4 [pSer457] Antibody
PRAS40 Phosphorylation of Thr246 LanthaScreen PRAS40 HEK293E K1528 LanthaScreen Tb-anti-PRAS40 [pThr246] Antibody
PRAS40 Phosphorylation of Ser183 LanthaScreen PRAS40 HEK293E K1528 LanthaScreen Tb-anti-PRAS40 [pSer183] Antibody
STAT1 Phosphorylation of Tyr701 LanthaScreen STAT1 U2OS K1469 LanthaScreen Tb-STAT1 [pTyr701] Antibody
STAT3 Phosphorylation of Tyr705 LanthaScreen STAT3 GripTite K1488 LanthaScreen Tb-STAT3 [pTyr705] Antibody
STAT5 Phosphorylation of Tyr694/Tyr699 LanthaScreen STAT5 TF-1 K1598 Anti-STAT5 A/B [pTyr694/699] Antibody
STAT5 Phosphorylation of Tyr694/Tyr699 LanthaScreen STAT5 U2OS (JAK2 V617F) K1588 Anti-STAT5 A/B [pTyr694/699] Antibody