Lysosomes are membrane-bound organelles essential to cell metabolism. They contain hydrolytic enzymes capable of digesting nearly all types of biomolecules including unused proteins, damaged organelles, and other unwanted materials in the cytoplasm from outside and inside the cell.
As a critical step in the autophagic pathway, an autophagosome containing cellular materials to be disposed fuses with a lysosome, and the contents of the autophagosome are degraded by the lysosome’s hydrolytic enzymes. This process is necessary for healthy cell function, and the failure of autophagy is responsible for a majority of cell damage accumulation and aging.
Lysosome marker antibodies detect proteins specific to the lysosome and can aid in the study of the structure and functions of lysosomes. Lysosome marker antibodies can also help elucidate the role or roles a protein may play in a number of tasks that are centered in or influenced by the lysosome. Additionally, lysosome marker antibodies are useful as tools to track the fusion of the lysosome with the autophagosome just before degradation of the autolysosome contents. Quality Invitrogen lysosome marker antibodies are available for your research needs.