Vanquish Duo UHPLC Systems

Three workflows. Two flow paths. One integrated UHPLC solution.

Improve your productivity and sample knowledge for a faster return on investment with the Thermo Scientific Vanquish Duo UHPLC systems. The Vanquish Duo UHPLC systems expand the benefits of the award-winning Vanquish platform with three workflows (Dual LC, Tandem LC or LC-MS and Inverse Gradient). Vanquish Duo UHPLC systems use a separate second flow path in one integrated system. Save time and cost per sample without added bench space, and without compromising performance, robustness or ease-of-use.

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Boost productivity without sacrifice

As a member of the Vanquish UHPLC product line, the Vanquish Duo UHPLC systems share all Vanquish-inherent values, such as a design focus on uptime, robustness and reliability.

  • The Thermo Scientific Vanquish Dual Split Sampler and Thermo Scientific Dual Pump extends the flexibility of the Vanquish UHPLC product line, ensuring the highest productivity and fastest return on investment in a single instrument bench space.
  • Multiple detection options designed for Vanquish gives you the freedom to choose for optimum data and the performance you need.
  • Thermo Scientific Viper Fingertight Fitting connections throughout the system make set up easy.

Also benefit from the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality. It also provides direct plugins for the Vanquish Duo UHPLC systems to other manufacturers' chromatography data systems.


Choose from three Vanquish Duo UHPLC systems

Vanquish Duo system for Dual LC

Dual LC workflow

Double your throughput or deepen your sample knowledge. Run the same method on both flow paths or two different methods simultaneously on one instrument, improving your lab productivity, sample knowledge, bench space usage and overall return on investment.

Build a Vanquish Duo for Dual LC to fit your application needs.

Vanquish Duo system for Dual LC

  • Improve return on investment by reducing cost per sample
  • Increase sample throughput without changing validated methods
  • Increase output without sacrificing bench space
  • Analyze the same set of samples with multiple methods reducing sample preparation time and maximizing sample information

Vanquish Duo system for Tandem LC or LC-MS

Tandem LC workflow

Ready to improve your lab throughput and get the most out of your detector or mass spectrometer? The Vanquish Duo system for Tandem LC or LC-MS system accomplishes this by running your analysis on two pumps and two columns all on one system. Deliver the analytical gradient on the first pump; while the second pump reconditions the column—preparing for the next injection.

Vanquish Duo system for Tandem LC or LC-MS

  • Increase sample throughput without modifying a validated method
  • Improve return on investment by maximizing the instrument utilization
  • Reduce column carry over through extended column washing without sacrificing throughput
  • Simplify method setup with automatic method conversion from your original gradient method

Inverse Gradient

Inverse gradient LC workflow

Improve your ability to detect and quantify all compounds in your sample with universal Charged Aerosol Detection using an Inverse Gradient. Advance your quantification of unknowns, without internal standards, and see what you’ve been missing.

Vanquish Duo for Inverse Gradient

  • Uniform response with charged aerosol detection under gradient elution conditions
  • Simplifying method setup with automatic Inverse Gradient calculation considering all system volumes
  • Reliable standard free quantification of knowns and unknowns

Vanquish Duo system for Dual LC

Dual LC workflow

Double your throughput or deepen your sample knowledge. Run the same method on both flow paths or two different methods simultaneously on one instrument, improving your lab productivity, sample knowledge, bench space usage and overall return on investment.

Build a Vanquish Duo for Dual LC to fit your application needs.

Vanquish Duo system for Dual LC

  • Improve return on investment by reducing cost per sample
  • Increase sample throughput without changing validated methods
  • Increase output without sacrificing bench space
  • Analyze the same set of samples with multiple methods reducing sample preparation time and maximizing sample information

Vanquish Duo system for Tandem LC or LC-MS

Tandem LC workflow

Ready to improve your lab throughput and get the most out of your detector or mass spectrometer? The Vanquish Duo system for Tandem LC or LC-MS system accomplishes this by running your analysis on two pumps and two columns all on one system. Deliver the analytical gradient on the first pump; while the second pump reconditions the column—preparing for the next injection.

Vanquish Duo system for Tandem LC or LC-MS

  • Increase sample throughput without modifying a validated method
  • Improve return on investment by maximizing the instrument utilization
  • Reduce column carry over through extended column washing without sacrificing throughput
  • Simplify method setup with automatic method conversion from your original gradient method

Inverse Gradient

Inverse gradient LC workflow

Improve your ability to detect and quantify all compounds in your sample with universal Charged Aerosol Detection using an Inverse Gradient. Advance your quantification of unknowns, without internal standards, and see what you’ve been missing.

Vanquish Duo for Inverse Gradient

  • Uniform response with charged aerosol detection under gradient elution conditions
  • Simplifying method setup with automatic Inverse Gradient calculation considering all system volumes
  • Reliable standard free quantification of knowns and unknowns

Overview of the Vanquish Duo Systems

    Vanquish Duo system for Dual LC Vanquish Duo system for Tandem LC or LC-MS Vanquish Duo system for Inverse Gradient
Workflow Benefits Improved return on investment*
* Calculate your savings
 
Double throughput or increase sample knowledge
 
Increased detector utilization
 
Reliable quantification with CAD
Saves bench space      
Easy-to-use      
Doubled sample throughput      
Run complementary assays      
Increased throughput for LC-MS      
Reliably quantify unknowns      
Dedicated workflow kits Vanquish Duo for Dual LC Workflow Kit Vanquish Duo for
Tandem LC or LC-MS
Workflow Kit
Vanquish Duo for Inverse Gradient Workflow Kit
System Features Design Modular Modular Modular
SmartInject technology for unsurpassed retention time precision      
SmartFlow technology for excellent flow precision      
Active and passive solvent pre-heating      
Multi-mode column thermostatting      
Sample cooling  
Temperature range:
4 – 40 °C
 
Temperature range:
4 – 40 °C
 
Temperature range:
4 – 40 °C
System Components Pump One:
Vanquish Dual Pump F

Or

A combination of two individual Vanquish pumps:
Autosampler Vanquish Dual Split Sampler FT
For applications up to 1000 bar

Or

Vanquish Dual Split Sampler HT
For applications up to 1500 bar
Vanquish Split Sampler FT
For applications up to 1000 bar

Or

Vanquish Split Sampler HT
For applications up to 1500 bar
Extended Sample Capacity Vanquish Charger (optional)
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management.
Column compartment 1 or 2 column compartments depending on application 1 column compartment
Vanquish Column Compartment
Provides two column thermostatting modes (still and forced air), active and passive solvent pre-conditioning and post-column cooling for optimized control of your separations and advanced method transfer.
Detectors A combination of two detectors: Any detector(s): Vanquish Charged Aerosol Detector
(Optional second detector)
Virtually zero dead volume system connections Viper UHPLC Fittings Kits
Order all the UHPLC fittings and capillaries you need for your system or application in a single kit

Compatible components for all Vanquish UHPLC systems

Detector options Vanquish columns Chromeleon CDS
Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before.
All Vanquish systems can be used with any of our HPLC and UHPLC columns
  • Streamlines your data processing
  • Industry-leading ease of use and intelligent functionalities
  • Outstanding data integrity
  • Unique user guidance and hardware automation features designed for Vanquish systems

Discover the best HPLC systems for your applications and budget

Discover the best HPLC system for your applications and budget

Use these 2 tools to help you decide

HPLC Systems Selection Guide
Use this tool to rank the top HPLC instruments for your applications based on your responses to simple pull-down menus.

HPLC System Total Cost of Ownership Calculator
Use this tool to estimate your cost for purchasing and running Thermo Scientific HPLC and UHPLC systems. You can compare costs between instruments.


Not sure which system is right for you?

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Featured video

Hear how Thermo Scientific Vanquish Duo UHPLC systems improve productivity with three workflows: tandem LC or LC-MS, dual LC, or inverse gradient.


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