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Thermo Fisher Scientific Debuts Novel Temperature-Responsive Cell Culture Surface At ACHEMA 2009

Thermo Scientific Nunc UpCell Surface Facilitates Enzyme-Free Harvesting of Single Cells and Tissue Engineering without Scaffolds

FRANKFURT (May 11, 2009) - Thermo Fisher Scientific Inc., the world leader in serving science, will debut its new Nunc™ UpCell™ Surface for temperature-induced cell harvesting at ACHEMA 2009. Designed to enable quick dissociation of cells from the culture surface upon a simple change in temperature, the Nunc UpCell Surface negates the need for enzymatic treatment (trypsinization) and cell scraping, while maintaining cell viability and the integrity of surface receptors and antigens. Even cell types that are difficult to detach by other methods and contiguous cell sheets can be harvested from the Nunc UpCell Surface, and harvested cell sheets can be stacked on top of each other in order to create 3-D tissue models and co-cultures. The Nunc UpCell Surface is available as sterile MicroWell™ plates, dishes and multi-dishes, all with a certificate stating conformance to functional, sterility, non-pyrogenic and toxicity tests. The UpCell will be showcased on booth B1-C11, Hall 6.1 at ACHEMA 2009 in Frankfurt, Germany, from May 11-15.

The novel Nunc UpCell surface consists of a covalently-immobilized polymer poly(N-isopropylacrylamide), or PIPAAm, which forms a thin, even layer on the culture dish or plate. Slightly hydrophobic at 37°C, the surface allows cells to attach and grow, but hydrophilic when the temperature is reduced to below 32°C, the surface will bind water and swell, resulting in the release of adherent cells with their underlying extracellular matrix (ECM). The retention of the ECM under the cells enables the harvesting of contiguous cell sheets with preserved cell polarization and cell-cell junctions and the attachment of one cell sheet to another cell sheet or a graft site without the use of fibrin glue or sutures. 3-D tissue models and co-cultures can thus be created without scaffolds and exogenous materials, greatly simplifying cell culture for tissue engineering.

For more information on the benefits of the new Thermo Scientific Nunc UpCell Surface and to see how this could transform cultures, please visit the Thermo Scientific booth B1-C11 in Hall 6.1 at ACHEMA 2009. Alternatively please visit www.thermo.com/UpCell.

UpCell Surface is licensed from CellSeed Inc. in Japan.

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

For a full list of all press releases announcing new products at ACHEMA 2009, please visit the online media room at www.thermofisher.com/achema09.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With annual revenues of $10.5 billion, we have approximately 34,000 employees and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. The Thermo Scientific brand represents a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit www.thermofisher.com.

For further press information please contact: Clare Russell, Alto Marketing Tel: +44 (0)1489 557672 Email: clarer@alto-marketing.com

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