ZO-1 / TJP1 Antibody, FITC conjugate (ZO1-1A12)

Catalog number: 339111

Invitrogen™  Related applications: Cell Structure | Cellular Imaging | Protein Assays and Analysis

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Description

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane- associated guanylate kinase (MAGUK) family and include occludin, ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Human, Canine
Validated Application: ELISA, Western Blot, Immunofluorescence
Host Species: Mouse
Clonality: Monoclonal
Clone ID: ZO1-1A12
Target Gene: ZO-1
Gene ID: 7082
Label or Dye: FITC (Fluorescein)
Excitation⁄Emission (nm): 488⁄525
Purification: Affinity Purified
Product Size: 100 µg
Shipping Condition: Wet Ice

Contents & storage

Store in refrigerator (2–8°C).

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