MHC Class II (I-A / I-E) Antibody (M5/114.15.2), Pacific Blue™ conjugate, Molecular Probes™

Catalog number: A14901

Invitrogen™  Related applications: Flow Cytometry

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Description

MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Mouse
Validated Application: Flow Cytometry
Host Species: Rat
SubClass (Isotype): IgG2b
Clonality: Monoclonal
Clone ID: M5/114.15.2
Antibody Fragment: Whole Antibody
Target Gene: I-A/I-E
Gene ID: 14961, 4969
Gene Symbol: H2-Ab1⁄H2-Eb1
Gene Aliases: Ia4, H2Eb, Ia-4, H-2Eb, Iab, Ia2, Ia-2, Abeta, H-2Ab, H2-Ab, Rmcs1, I-Abeta, AI845868
Label or Dye: Pacific Blue™
Excitation⁄Emission (nm): 405⁄455
Concentration: 0.5 mg⁄ml
Form: Liquid
Number of Reactions: 100 Tests
For Use With (Equipment): Flow Cytometer, Attune® Acoustic Focusing Cytometer
Product Size: 25 µg
Other Additives: Sodium Azide Preservative
Shipping Condition: Wet Ice

Contents & storage

Store at 2-8°C

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