LRRK2 G2019S Full Length Protein

Catalog number: A15201

 Related applications: Protein Assays and Analysis | Target & Lead Identification & Validation

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Your price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}}
also known as {{product.formattedSku}} 
{{subscriptionDetails.selectedRatePlan.billingPeriod}} {{subscriptionDetails.selectedRatePlan.billingPeriod}} {{product.availability.message}}
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top

Description

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
Uncover novel compounds or hits specific to the full-length form
Advance Parkinson's research using the full-length protein and validated assays

Related Links:
LRRK2 tools for advancing Parkinson's disease research
Kinase protein portfolio
LanthaScreen® Eu Kinase Binding Assay
LanthaScreen® TR-FRET Kinase Activity Assay
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Species: Human
Gene Aliases: AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Product Size: 100 µg
Accession Number: NP_940980.3
Molecular Weight: 288 kDa
Research Category: Neurobiology
Validated Application: Kinase Assay
Protein Tag or Fusion: DYKDDDDK
Expression: Mammalian
Kinase Family: LRRK Kinase Family
Protein Form: Full Length

Contents & storage

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.

Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton®X–100, 2 mM DTT, and 50% glycerol.

Documents

Manuals & protocols

Recommended products