TRAIL-R2 / DR5 Antibody (DJR2-4), PE conjugate, Molecular Probes™

Catalog number: A18431

Invitrogen™  Related applications: Flow Cytometry

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Description

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappa-B.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Human
Validated Application: Flow Cytometry
Host Species: Mouse
SubClass (Isotype): IgG1, kappa
Clonality: Monoclonal
Clone ID: DJR2-4
Antibody Fragment: Whole Antibody
Target Gene: CD262
Gene ID: 8795
Gene Symbol: TNFRSF10B
Gene Aliases: DR5, TNFRSF10B, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2
Label or Dye: R-PE
Excitation⁄Emission (nm): 496⁄578
Excitation Class: Visible
Concentration: 0.05 mg⁄ml
Form: Liquid
Number of Reactions: 25 Tests
For Use With (Equipment): Attune® Acoustic Focusing Cytometer
Product Size: 25 tests
Other Additives: Sodium Azide Preservative

Contents & storage

Store in refrigerator (2–8°C).

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Manuals & protocols

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