p53 Antibody (B-P3)

Catalog number: AHO0032

Invitrogen™  Related applications: Cell Viability, Proliferation & Function | Cellular Imaging | Oncology & Genetic Disease Research

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Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Human
Validated Application: Immunohistochemistry, Functional Studies
Host Species: Mouse
Clonality: Monoclonal
Clone ID: B-P3
Target Gene: p53
Gene ID: 7157
Label or Dye: Unconjugated
Product Size: 100 µg
Research Category: Oncology
Purity or Quality Grade: Azide Free
Shipping Condition: Approved for shipment on Wet or Dry Ice

Contents & storage

Store in refrigerator (2–8°C).

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