Human MRP1 Vesicles

Catalog number: GM0010

Gibco™  Related applications: Target-Based ADME⁄Tox Assays

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Description

Human MRP1 Vesicles are insect derived purified plasma membranes with inserted MRP1 transport protein (multidrug resistance-associated protein 1, ABCC1). Our Human MRP1 Vesicles can be used to evaluate test compounds and drug interactions with MRP1 in in vitro assays. MRP1 is an ATP-binding cassette (ABC) transporter that carries organic anions.

Use Human MRP1 Vesicles to:

• Investigate the transporter interactions of your drug candidates
• Assess potential for transporter-mediated drug-drug interactions
• Obtain high quality results with a large signal to noise ratios

Concept Behind ABC Transporter Vesicles
ABC transporter vesicles are easy-to-use, efficient reagents for early assessment of a drug candidate's substrate and drug interaction potential. While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles. It is therefore possible to quantitatively evaluate transport activity for your compound by determining the amount incorporated into the vesicles.

Clear and Reliable Results
Prepared from Sf9 cells which have been engineered to over-express specific ABC transporters, these "inside-out" vesicles provide high levels of transporter activity with low background, giving you a clear signal if your compound is a substrate or inhibitor of a specific efflux transporter.

Transporter Vesicle Details
Human MRP1 Vesicles are part of a larger group of transporter vesicles known as ABC transporter vesicles. They are prepared from purified plasma membranes isolated from an insect cell system (Sf9 cells transfected with baculovirus) expressing MRP1. MRP1 is expressed in various normal organs, and also in tumor cells. MRP1 is associated with multidrug resistance to anti-cancer drugs.

For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Format: Vial(s)
Form: Frozen
Species: Human
Product Size: 0.5 mL
Shipping Condition: Dry Ice
Purity or Quality Grade: Research Grade

Contents & storage

Store at -80°C.

Documents

Manuals & protocols

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