CD16 / FCGR3 Antibody (3G8), Pacific Orange™ conjugate, Molecular Probes™

Catalog number: MHCD1630

Invitrogen™  Related applications: Flow Cytometry

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Description

Our Pacific Orange™ dye is optimally excited by the violet laser, and it is recommended that a 575, 585 or 600 nm band pass filter be used for optimal detection. Pacific Blue™ and Pacific Orange™ dye conjugates can be simultaneously excited at 405 nm and emit at 455 nm and 551 nm, respectively, facilitating two-color analysis.

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Analyte Specific Reagent. Analytical and performance characteristics are not established.

Specifications

Reactivity: Human
Validated Application: Flow Cytometry
Host Species: Mouse
SubClass (Isotype): IgG1
Clonality: Monoclonal
Clone ID: 3G8
Antibody Fragment: Whole Antibody
Target Gene: CD16
Gene ID: 2214
Label or Dye: Pacific Orange™
Excitation⁄Emission (nm): 405⁄551
Purification: Affinity Purified
Form: Liquid
Number of Reactions: 100 Tests
For Use With (Equipment): Flow Cytometer
Product Size: 0.5 ml
Quantity: 1
Shipping Condition: Wet Ice

Contents & storage

CD16, Mouse anti-human, (Pacific Orange™), 0.5 mL in PBS with 0.1% sodium azide. Store reagents at 2-8°C.

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