Research indicates that genetic variations are key for understanding the genetic basis of complex traits and diseases. Variants can influence phenotypes, the susceptibility of an individual to disease, drug response and human genome evolution. Many SNPs have been associated with common disorders such as diabetes, obesity, and cardiovascular diseases. Further research into identifying the risk factors and understanding the biology of risk variants would enable a more complete view of these conditions and lead to improved disease treatment and prevention.
The APOE gene has three common alleles: ApoE2, ApoE3, and ApoE4. Research suggests that the ApoE4 allele (rs429358-C + rs7412-C) is associated with increased total serum cholesterol and coronary heart disease and increased risk of Alzheimer's disease. Research also suggests the ApoE2 allele (rs429358-T + rs7412-T) may have a protective effect against Alzheimer's disease and is associated with longevity.