Research indicates that genetic variations are key for understanding the genetic basis of complex traits and diseases. Variants can influence phenotypes, the susceptibility of an individual to disease, drug response and human genome evolution. Many SNPs have been associated with common disorders such as diabetes, obesity, and cardiovascular diseases. Further research into identifying the risk factors and understanding the biology of risk variants would enable a more complete view of these conditions and lead to improved disease treatment and prevention.
Studies show that the Pro12Ala polymorphism in exon 2 of PPARG reduces transcriptional activity of PPARγ2 and may be associated with increased insulin sensitivity and protection from Type 2 Diabetes.
Peroxisome Proliferator-activated Receptor Gamma