ABL1, ABL2, ACTR2, ACTR3, ARHGEF1, ARHGEF11, ARHGEF2, ARHGEF6, ARHGEF7, BDNF, CABLES1, CDC42, CDK5, CFL1, CFL2, CRMP1, DAB1, DCC, DPYSL5, DSCAM, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EPHA1, EPHA2, EPHA3, EPHA4, EPHA7, FES, FYN, GDAP1, GSN, LIMK1, LIMK2, LRP8, MAG, MAPK8IP2, MYL1, MYL2, MYL3, MYL4, MYL9, NCK1, NGEF, NGF, N...GFR, NRP1, NTN1, NTRK1, NTRK2, NTRK3, PAK1, PAK2, PAK3, PAK4, PAK7, PIK3CA, PIK3CB, PIK3R1, PIK3R2, PLCG1, PLCG2, PLXNA1, PLXNB1, RAC1, RAC2, RAC3, RASA1, RELN, RHOA, RHOB, RHOC, RHOG, RND3, ROBO1, ROCK1, ROCK2, RTN4R, SEMA3A, SEMA4D, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5C, VLDLR, WASL
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As an axon grows, the growth cone at its advancing edge encounters specific 'choice points' at which guidance cues steer specific axons towards their appropriate destinations. Such cues may attract a subset of axons towards a given domain, repel axons fro ...m inappropriate target regions or simply provide a permissive substrate for axonal outgrowth. There are many different ways in which a guidance signal might intervene to steer the growth cone. For example, a guidance cue might promote the initiation, extension, stabilization, or retraction of individual filopodia, or the capture or stabilization of microtubules in specific regions of the growth cone. In each of these cases, guidance signals must be relayed through the growth cone to the Actin cytoskeleton, a dynamic network of filaments and associated proteins that are largely responsible for motility and growth cone steering. Many diffusible and membrane-bound factors have been proposed as potential guidance cues in different systems. In some cases, it is Netrins and Semaphorin, and in other cases, it is Ephrin, 14-3-3 or Neurotrophin.
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